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The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

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An Erratum to this article was published on 31 December 2011

Abstract

The aim of this study was to investigate the effect of 400 ml whole blood donation on the human electroencephalogram (EEG) and hematology, not earlier reported in the literature. EEG activity was recorded from ten male blood donors (experiment group) before, during and after blood donation (i.e., 400 ml whole blood withdrawal). EEG topography and regional spectral field powers analyses were carried out via fast Fourier transformation. The venous hemoglobin (Hb) concentration was measured with a hematology analyzer. In the control investigation, 12 male age-matched volunteers (control group) were kept in semi-sitting position for the duration of a blood donation without actually vena puncture. The volunteers had no prior experiences of blood donation. Within the experiment group, post-donation Hb concentration decreased by 3.7% compared with the pre-donation Hb values (P < 0.01). Before blood donation, Hb concentration in control group was significantly higher compared to the experiment group (P < 0.05). For the experiment group, the field power of alpha-1 (7.5–9.5 Hz) EEG during blood withdrawal was significantly lower compared to that after blood withdrawal (P < 0.05). In contrast for the control group, all seven bands of regional spectral field powers showed no significantly discrepancies in the three periods. Blood donation attenuates the alpha-1 at the parietal–frontal area on human EEG-DMN transiently with no lasting effect at post-donation period. The blood donation-related effects on brain function may be of little consequence due to slight hemodynamic change and the results may facilitate the opinion that blood donation is a safe process and that should not discourage volunteers.

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Acknowledgments

The project is supported by Chinese National Science Fund (NSF 30770691) grant.

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Authors and Affiliations

  1. Center for Higher Brain Functions, Capital Medical University, Beijing, 100069, China

    Mingxia Zhang, Jie Ynag & Andrew C. N. Chen

  2. Linfen Blood Bank, Linfen, 041000, Shanxi, China

    Gencang Zhang

Authors
  1. Mingxia Zhang
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  2. Gencang Zhang
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  3. Jie Ynag
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  4. Andrew C. N. Chen
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Corresponding author

Correspondence to Andrew C. N. Chen.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10548-011-0215-9

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Zhang, M., Zhang, G., Ynag, J. et al. The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors. Brain Topogr 25, 116–123 (2012). https://doi.org/10.1007/s10548-011-0203-0

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  • DOI: https://doi.org/10.1007/s10548-011-0203-0

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