Summary
We report a patient with carnitine palmitoyltransferase I (CPT I) deficiency, who presented with acute encephalopathy at 6 months of age. This was precipitated by an episode of gastroenteritis. No hypoglycaemia was documented, but there was hepatomegaly; blood tests revealed raised transaminases, a coagulopathy and severe hypertriglyceridaemia (48.8 mmol/L) and hypercholesterolaemia (9.5 mmol/L). The hyperlipidaemia resolved within 3 days of treatment and did not recur. At 2 years of age, the patient’s liver function, growth and development are all normal. Hyperlipidaemia has been reported during acute illness in previous patients with CPT I deficiency but it is not a well-recognized feature; it should alert metabolic specialists to this potential diagnosis.
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Communicating editor: Michael Bennett
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Worthington, H., Olpin, S.E., Blumenthal, I. et al. Hyperlipidaemia due to carnitine palmitoyltransferase I deficiency. J Inherit Metab Dis 30, 104 (2007). https://doi.org/10.1007/s10545-006-0480-z
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DOI: https://doi.org/10.1007/s10545-006-0480-z