Abstract
A biosensor is a compact device, which utilizes biological derived recognition component, immobilized on a transducer to analyze an analyte. Nanoparticles with their unique chemical and physical properties are versatile in their applications to develop as sensors. Different nanoparticles play different roles in the sensing systems like metal and metal oxide nanoparticles. The application of Gold, Silver and Copper nanoparticles will be discussed in brief. The nanoparticles typically function as substrates for immobilization of biomolecules, as catalytic agent, electron transfer agent between electrode surface and the biomolecules, and as reactants. Microfluidic deals with manipulating very small volumes of fluids (micro and nanoliters). This miniaturized platform enhances control of flow conditions and mixing rate of fluids. The microfluidics improves the sensitivity of the analysis, and reduces the volumes of sample and reagent in the analysis. The review specifically aims at representing microfluidics-based sensors and nanoparticle based sensors. This review will also focus on probable merger of these two fields to take advantage of both the fields and this will help in pushing the boundaries of these fields further more.
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R. Abedini-Nassab, M.P. Miandoab, M. Şaşmaz, Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review. Micromachines. 12(7), 768 (2021). https://doi.org/10.3390/MI12070768
S. Akbari Nakhjavani, H. Afsharan, B. Khalilzadeh, M.H. Ghahremani, S. Carrara, Y. Omidi, Gold and silver bio/nano-hybrids-based electrochemical immunosensor for ultrasensitive detection of carcinoembryonic antigen. Biosens. Bioelectron. (2019). https://doi.org/10.1016/j.bios.2019.111439
N. Bhalla, P. Jolly, N. Formisano, P. Estrela, Introduction to biosensors. Essays Biochem. 60(1), 1–8 (2016). https://doi.org/10.1042/EBC20150001
C.C. Chang, S.C. Wei, T.H. Wu, C.H. Lee, C.W. Lin, Aptamer-based colorimetric detection of platelet-derived growth factor using unmodified gold nanoparticles. Biosens. Bioelectron. (2013). https://doi.org/10.1016/j.bios.2012.10.072
C. Chen, J. Wang, Optical biosensors: An exhaustive and comprehensive review. In Analyst (2020). https://doi.org/10.1039/c9an01998g
A.K.H. Cheng, B. Ge, H.Z. Yu, Aptamer-based biosensors for label-free voltammetric detection of lysozyme. Anal. Chem. (2007). https://doi.org/10.1021/ac062214q
S.R. Chinnadayyala, M. Santhosh, N.K. Singh, P. Goswami, Alcohol oxidase protein mediated in-situ synthesized and stabilized gold nanoparticles for developing amperometric alcohol biosensor. Biosens. Bioelectron. 69, 155–161 (2015). https://doi.org/10.1016/j.bios.2015.02.015
J. Choo, C. Lim, L. Chen, H. Chon, G. Wang, J. Hong, A.J. Demello, Surface-enhanced Raman scattering in nanoliter droplets: Towards high-sensitivity detection of mercury (II) ions. Anal. Bioanal. Chem. 394(7), 1827–1832 (2009). https://doi.org/10.1007/s00216-009-2832-7
A.F. Chrimes, K. Khoshmanesh, P.R. Stoddart, A.A. Kayani, A. Mitchell, H. Daima, V. Bansal, K. Kalantar-zadeh, Active control of silver nanoparticles spacing using dielectrophoresis for surface-enhanced raman scattering. Anal. Chem. 84(9), 4029–4035 (2012). https://doi.org/10.1021/ac203381n
L.C. Clark, C. Lyons, Electrode systems for continuous monitoring in cardiovascular surgery. Ann. n. y. Acad. Sci. (1962). https://doi.org/10.1111/j.1749-6632.1962.tb13623.x
A.F. Collings, F. Caruso, Biosensors: Recent advances. Rep. Prog. Phys. (1997). https://doi.org/10.1088/0034-4885/60/11/005
R.M. Connatser, L.A. Riddle, M.J. Sepaniak, Metal-polymer nanocomposites for integrated microfluidic separations and surface enhanced Raman spectroscopic detection. J. Sep. Sci. (2004). https://doi.org/10.1002/jssc.200401886
S. Cosnier, Electrochemical biosensors. In Electrochemical Biosensors (2014). https://doi.org/10.1081/e-eafe2-120051918
P.R. Coulet, L.J. Blum, Biosensor Principles and Applications. (1991).
P. Damborský, J. Švitel, J. Katrlík, Optical biosensors. Essays Biochem. (2016). https://doi.org/10.1042/EBC20150010
R. Devasenathipathy, V. Mani, S.M. Chen, S.T. Huang, T.T. Huang, C.M. Lin, K.Y. Hwa, T.Y. Chen, B.J. Chen, Glucose biosensor based on glucose oxidase immobilized at gold nanoparticles decorated graphene-carbon nanotubes. Enzyme Microb. Technol. 78(2015). https://doi.org/10.1016/j.enzmictec.2015.06.006
A. El-Ansary, L.M. Faddah, Nanoparticles as biochemical sensors. Nanotechnol. Sci. Appl. 3, 65–76 (2010). https://doi.org/10.2147/NSA.S8199
P.A. Emanuel, J. Dang, J.S. Gebhardt, J. Aldrich, E.A.E. Garber, H. Kulaga, P. Stopa, J.J. Valdes, A. Dion-Schultz, Recombinant antibodies: A new reagent for biological agent detection. Biosens. Bioelectron. (2000). https://doi.org/10.1016/S0956-5663(99)00058-5
X. Fan, I.M. White, S.I. Shopova, H. Zhu, J.D. Suter, Y. Sun, Sensitive optical biosensors for unlabeled targets : A review. 8(26) (2008). https://doi.org/10.1016/j.aca.2008.05.022
D. Figeys, D. Pinto, Lab-on-a-chip: A revolution in biological and medical sciences. In Analytical Chemistry (2000). https://doi.org/10.1021/ac002800y
A. Garrido-Maestu, S. Azinheiro, J. Carvalho, S. Abalde-Cela, E. Carbó-Argibay, L. Diéguez, M. Piotrowski, Y.V. Kolen’ko, M. Prado, Combination of microfluidic loop-mediated isothermal amplification with gold nanoparticles for rapid detection of Salmonella spp. in food samples. Front. Microbiol. 8(2017). https://doi.org/10.3389/fmicb.2017.02159
L. Ge, S. Wang, X. Song, S. Ge, J. Yu, 3D Origami-based multifunction-integrated immunodevice: Low-cost and multiplexed sandwich chemiluminescence immunoassay on microfluidic paper-based analytical device. Lab Chip (2012). https://doi.org/10.1039/c2lc40325k
Z. Geng, W. Liu, X. Wang, F. Yang, A route to apply Ag nanoparticle array integrated with microfluidic for surface enhanced Raman scattering. Sens. Actuators, A 169(1), 37–42 (2011). https://doi.org/10.1016/j.sna.2011.05.001
D. Ghosh, N. Chattopadhyay, Gold and silver nanoparticles based superquenching of fluorescence: A review. In Journal of Luminescence (2015). https://doi.org/10.1016/j.jlumin.2014.12.018
D. Grieshaber, R. MacKenzie, J. Vörös, E. Reimhult, Electrochemical biosensors - Sensor principles and architectures. In Sensors (2008). https://doi.org/10.3390/s8031400
Z. Guo, W.A. Johnston, V. Stein, P. Kalimuthu, S. Perez-Alcala, P.V. Bernhardt, Kirill Alexandrov, ChemComm. 52(3), 485–488 (2016). https://doi.org/10.1039/C5CC07824E
Z.X. Guo, Q. Zeng, M. Zhang, L.Y. Hong, Y.F. Zhao, W. Liu, S.S. Guo, X.Z. Zhao, Valve-based microfluidic droplet micromixer and mercury (II) ion detection. Sens. Actuators, A (2011). https://doi.org/10.1016/j.sna.2011.09.019
N. Hernández Ibáñez, L. García-Cruz, V. Montiel, C. Foster, C. Banks, J. Iniesta, Electrochemical lactate biosensor based upon chitosan/carbon nanotubes modified screen-printed graphite electrodes for the determination of lactate in embryonic cell cultures. Biosens. Bioelectron. 77(2015). https://doi.org/10.1016/j.bios.2015.11.005
T.R.J. Holford, F. Davis, S.P.J. Higson, Recent trends in antibody based sensors. Biosens. Bioelectron. (2012). https://doi.org/10.1016/j.bios.2011.10.023
D. Holmes, S. Gawad, The application of microfluidics in biology. In Methods in molecular biology (Clifton, N.J.) (Vol. 583, pp. 55–80) (2010). https://doi.org/10.1007/978-1-60327-106-6_2
M.F. Hossain, J.Y. Park, Plain to point network reduced graphene oxide - activated carbon composites decorated with platinum nanoparticles for urine glucose detection. Sci. Rep. 6(1)(2016). https://doi.org/10.1038/srep21009
S. Hosseini, F. Ibrahim, I. Djordjevic, L.H. Koole, Recent advances in surface functionalization techniques on polymethacrylate materials for optical biosensor applications. In Analyst (2014). https://doi.org/10.1039/c3an01789c
D. Hou, S. Maheshwari, H.-C. Chang, Rapid bioparticle concentration and detection by combining a discharge driven vortex with surface enhanced Raman scattering. Biomicrofluidics. 1(1), 014106 (2007). https://doi.org/10.1063/1.2710191
Y.H. Hou, J.-J. Wang, Y.-Z. Jiang, C. Lv, Li. Xia, S.-L. Hong, M. Lin, Y. Lin, Z.-L. Zhang, D.-W. Pang, A colorimetric and electrochemical immunosensor for point-of-care detection of enterovirus 71. Biosens Bioelectron 99, 186–192 (2018). https://doi.org/10.1016/j.bios.2017.07.035
P. Jarujamrus, R. MMeelapso, S. Pencharee, A. Obma, M. Amatatongchai, N. Ditcharoen, S. Chairam, S. Tamuang, Use of a smartphone as a colorimetric analyzer in paper-based devices for sensitive and selective determination of mercury in water samples. Anal. Sci. 34(1), 75–81 (2018). https://doi.org/10.2116/analsci.34.75
S.D. Jayasena, Aptamers: An emerging class of molecules that rival antibodies in diagnostics. Clin. Chem. (1999). https://doi.org/10.1093/clinchem/45.9.1628
M.H. Jazayeri, T. Aghaie, A. Avan, A. Vatankhah, M.R.S. Ghaffari, Colorimetric detection based on gold nano particles (GNPs): An easy, fast, inexpensive, low-cost and short time method in detection of analytes (protein, DNA, and ion). Sensing and Bio-Sensing Research 20, 1–8 (2018). https://doi.org/10.1016/J.SBSR.2018.05.002
Y. Jiang, H. Wang, S. Li, W. Wen, Applications of micro/nanoparticles in microfluidic sensors: a review. Sensors (basel, Switzerland) 14(4), 6952–6964 (2014). https://doi.org/10.3390/S140406952
C.I.L. Justino, A.C. Freitas, R. Pereira, A.C. Duarte, T.A.P. Rocha Santos, Recent developments in recognition elements for chemical sensors and biosensors. In TrAC - Trends in Analytical Chemistry (2015). https://doi.org/10.1016/j.trac.2015.03.006
K. Kalantar-Zadeh, B. Fry, Nanotechnology-enabled sensors. In Nanotechnology-Enabled Sensors (2008). https://doi.org/10.1007/978-0-387-68023-1
C. Karunakaran, R. Rajkumar, K. Bhargava, Introduction to Biosensors. In Biosensors and Bioelectronics (2015). https://doi.org/10.1016/B978-0-12-803100-1.00001-3
M. Kataria, M. Swati, T. Pathak, K. Kumar, Enzyme based biosensors and their applications. In Industrial Enzymes: Trends, Scope and Relevance (pp. 157–172). Nova Science Publishers, Inc. (2014). https://doi.org/10.1016/b978-0-444-64114-4.00008-x
R. Keir, E. Igata, M. Arundell, W.E. Smith, D. Graham, C. McHugh, J.M. Cooper, SERRS. In situ substrate formation and improved detection using microfluidics. Anal. Chem. 74(7), 1503–1508 (2002). https://doi.org/10.1021/ac015625+
D.-M. Kim, M.-Y. Kim, S.S. Reddy, J. Cho, C.-H. Cho, S. Jung, Y.-B. Shim, Electron-transfer mediator for a NAD-glucose dehydrogenase-based glucose sensor. Anal. Chem. 85(23), 11643–11649 (2013). https://doi.org/10.1021/ac403217t
G. Köhler, C. Milstein, Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975). https://doi.org/10.1038/256495a0
M.B. Kulkarni, S. Goel, Microfluidic devices for synthesizing nanomaterials—a review. Nano Express 1(3), 032004 (2020). https://doi.org/10.1088/2632-959X/ABCCA6
B. Kuswandi, H. Nuriman, J., & Verboom, W. , Optical sensing systems for microfluidic devices: A review. In Analytica Chimica Acta (2007). https://doi.org/10.1016/j.aca.2007.08.046
J.P. Lafleur, A. Jönsson, S. Senkbeil, J.P. Kutter, Recent advances in lab-on-a-chip for biosensing applications. Biosens. Bioelectron. 76, 213–233 (2016). https://doi.org/10.1016/j.bios.2015.08.003
J.P. Lafleur, S. Senkbeil, T.G. Jensen, J.P. Kutter, Gold nanoparticle-based optical microfluidic sensors for analysis of environmental pollutants. Lab Chip. 12(22), 4651 (2012). https://doi.org/10.1039/c2lc40543a
J.R. Lakowicz, J.R. Lakowicz, Quenching of Fluorescence. In Principles of Fluorescence Spectroscopy (1999). https://doi.org/10.1007/978-1-4757-3061-6_8
K. Lata, V. Dhull, V. Hooda, Fabrication and optimization of ChE/ChO/HRP-AuNPs/c-MWCNTs based silver electrode for determining total cholesterol in serum. Biochem. Res. Int. 2016, 1–11 (2016). https://doi.org/10.1155/2016/1545206
D. Lee, J. Hwang, Y. Seo, A.A. Gilad, J. Choi, Optical Immunosensors for the Efficient Detection of Target Biomolecules. In Biotechnology and Bioprocess Engineering (2018). https://doi.org/10.1007/s12257-018-0087-x
B. Li, X. Li, Y. Dong, B. Wang, D. Li, Y. Shi, Y. Wu, Colorimetric Sensor Array Based on Gold Nanoparticles with Diverse Surface Charges for Microorganisms Identification. Anal. Chem. 89(20), 10639–10643 (2017). https://doi.org/10.1021/ACS.ANALCHEM.7B02594
F. Li, L. Guo, Z. Li, J. He, H. Cui, Temporal-spatial-color multiresolved chemiluminescence imaging for multiplex immunoassays using a smartphone coupled with microfluidic chip. Anal. Chem. 92(10), 6827–6831 (2020). https://doi.org/10.1021/acs.analchem.0c01405
L. Li, B. Li, Y. Qi, Y. Jin, Label-free aptamer-based colorimetric detection of mercury ions in aqueous media using unmodified gold nanoparticles as colorimetric probe. Anal. Bioanal. Chem. (2009). https://doi.org/10.1007/s00216-009-2640-0
L. Li, W. Li, C. Ma, H. Yang, S. Hongmei, JYu. Ge, Paper-based electrochemiluminescence immunodevice for carcinoembryonic antigen using nanoporous gold-chitosan hybrids and graphene quantum dots functionalized Au@Pt. Sens. Actuators B Chem. 202, 314–322 (2014). https://doi.org/10.1016/j.snb.2014.05.087
Y.T. Li, H.S. Liu, H.P. Lin, S.H. Chen, Gold nanoparticles for microfluidics-based biosensing of PCR products by hybridization-induced fluorescence quenching. Electrophoresis 26(24), 4743–4750 (2005). https://doi.org/10.1002/elps.200500481
B. Liang, L. Li, X.J. Tang, Q. Lang, H. Wang, F. Li, J. Shi, W. Shen, I. Palchetti, M. Mascini, A. Liu, Microbial surface display of glucose dehydrogenase for amperometric glucose biosensor. Biosens. Bioelectron. 45, 19–24 (2013). https://doi.org/10.1016/j.bios.2013.01.050
C. Lim, J. Ko, G. Wang, L. Chen, A. J. deMello, J. Hong, J. Choo, J, Surface-enhanced Raman scattering in picoliter droplets: Towards highly sensitive and selective detection of mercury ions. The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Jeju, Korea (MicroTAS, 2009), pp. 326–328
D.-Y. Liu, Y.-Y. Xin, X.-W. He, X.-B. Yin, The electrochemiluminescence of ruthenium complex/tripropylamine systems at DNA-modified gold electrodes. Biosens. Bioelectron. 26, 2703–2706 (2010). https://doi.org/10.1016/j.bios.2010.08.074
H. Liu, J. Liu, S. Li, L. Chen, H. Zhou, J. Zhu, Z. Zheng, Fiber-optic SERS microfluidic chip based on light-induced gold nano-particle aggregation. Optics Communications 352, 148–154 (2015). https://doi.org/10.1016/j.optcom.2015.04.084
Y, Liu, W.D. Wilson, Quantitative analysis of small molecule-nucleic acid interactions with a biosensor surface and surface plasmon resonance detection. Methods Mol Biol. (Clifton, N.J.) (2010). https://doi.org/10.1007/978-1-60327-418-0_1
E. Livak-Dahl, I. Sinn, M. Burns, Microfluidic chemical analysis systems. In Annual Review of Chemical and Biomolecular Engineering (2011). https://doi.org/10.1146/annurev-chembioeng-061010-114215
F. Long, A. Zhu, H. Shi, Recent advances in optical biosensors for environmental monitoring and early warning. In Sensors (switzerland) (2013). https://doi.org/10.3390/s131013928
G. Luka, A. Ahmadi, H. Najjaran, E. Alocilja, M. Derosa, K. Wolthers, A. Malki, H. Aziz, A. Althani, M. Hoorfar, Microfluidics integrated biosensors: A leading technology towards lab-on-A-chip and sensing applications. Sensors (switzerland) 15(12), 30011–30031 (2015). https://doi.org/10.3390/s151229783
J.H.T. Luong, K.B. Male, J.D. Glennon, Biosensor technology: Technology push versus market pull. In Biotechnology Advances (2008). https://doi.org/10.1016/j.biotechadv.2008.05.007
P.B. Luppa, L.J. Sokoll, D.W. Chan, Immunosensors - Principles and applications to clinical chemistry. In Clinica Chimica Acta (2001). https://doi.org/10.1016/S0009-8981(01)00629-5
D. Mark, S. Haeberle, G. Roth, F. Von Stetten, R. Zengerle, Microfluidic lab-on-a-chip platforms: Requirements, characteristics and applications. In Chemical Society Reviews 39(3), 1153–1182 (2010). https://doi.org/10.1039/b820557b
G. Mayer, The chemical biology of aptamers. In Angewandte Chemie - International Edition (2009). https://doi.org/10.1002/anie.200804643
R. Meelapsom, P. Jarujamrus, M. Amatatongchai, S. Chairam, C. Kulsing, W. Shen, Chromatic analysis by monitoring unmodified silver nanoparticles reduction on double layer microfluidic paper-based analytical devices for selective and sensitive determination of mercury(II). Talanta. 155, 193–201 (2016). https://doi.org/10.1016/j.talanta.2016.04.037
R.A. Meryam Sardar, Enzyme Immobilization: An Overview on Nanoparticles as Immobilization Matrix. Biochemistry & Analytical Biochemistry (2015). https://doi.org/10.4172/2161-1009.1000178
N.R. Mohamad, N.H.C. Marzuki, N.A. Buang, F. Huyop, R.A. Wahab, An overview of technologies for immobilization of enzymes and surface analysis techniques for immobilized enzymes. In Biotechnology and Biotechnological Equipment (2015). https://doi.org/10.1080/13102818.2015.1008192
M.J. Mulvihill, X.Y. Ling, J. Henzie, P. Yang, Anisotropic etching of silver nanoparticles for plasmonic structures capable of single-particle SERS. J. Am. Chem. Soc. (2010). https://doi.org/10.1021/ja906954f
F.G. Ortega, M.A. Fernández-Baldo, M.J. Serrano, G.A. Messina, J.A. Lorente, J. Raba, Epithelial cancer biomarker EpCAM determination in peripheral blood samples using a microfluidic immunosensor based in silver nanoparticles as platform. Sens. Actuators B Chem. 221, 248–256 (2015). https://doi.org/10.1016/j.snb.2015.06.066
L.J. Ou, S.W. Qin, H. Bo, J.X. Luo, N.C. Yuan, A.M. Sun, L.Y. Wang, W.H. Liu, A fluorescent signal-on sensor based on photoinduced electron transfer between copper nanoparticles and G-quadruplex/hemin. Anal. Methods 11(18), 2410–2414 (2019). https://doi.org/10.1039/c9ay00461k
T. Park, S. Lee, G.H. Seong, J. Choo, E.K. Lee, Y.S. Kim, W.H. Ji, S.Y. Hwang, D.G. Gweon, S. Lee, Highly sensitive signal detection of duplex dye-labelled DNA oligonucleotides in a PDMS microfluidic chip: confocal surface-enhanced Raman spectroscopic study. Lab Chip. 5(4), 437 (2005). https://doi.org/10.1039/b414457k
S.G. Penn, L. He, M.J. Natan, Nanoparticles for bioanalysis. In Current Opinion in Chemical Biology (2003). https://doi.org/10.1016/j.cbpa.2003.08.013
J.M. Pingarrón, P. Yáñez-Sedeño, A. González-Cortés, Gold nanoparticle-based electrochemical biosensors. Electrochim. Acta 53(19), 5848–5866 (2008). https://doi.org/10.1016/j.electacta.2008.03.005
K. Ponlakhet, M. Amatatongchai, W. Sroysee, P. Jarujamrus, S. Chairam, Development of sensitive and selective glucose colorimetric assay using glucose oxidase immobilized on magnetite–gold–folate nanoparticles. Anal. Methods. 8(47), 8288–8298 (2016). https://doi.org/10.1039/C6AY02850K
M. Rai, N. Duran, Metal Nanoparticles in Microbiology. In M. Rai & N. Duran (Eds.), Metal Nanoparticles in Microbiology. (2011). https://doi.org/10.1007/978-3-642-18312-6
V. Raj, A.N. Vijayan, K. Joseph, Cysteine capped gold nanoparticles for naked eye detection of E. coli bacteria in UTI patients. Sensing and Bio-Sensing Research 5, 33–36 (2015). https://doi.org/10.1016/J.SBSR.2015.05.004
N.B. Ramírez, A.M. Salgado, B. Valdman, The evolution and developments of immunosensors for health and environmental monitoring: Problems and perspectives. Braz. J. Chem. Eng. (2009). https://doi.org/10.1590/s0104-66322009000200001
L. Rassaei, F. Marken, M. Sillanpää, M. Amiri, C.M. Cirtiu, M. Sillanpää, Nanoparticles in electrochemical sensors for environmental monitoring. In TrAC - Trends in Analytical Chemistry. 30(11), 1704–1715 (2011). https://doi.org/10.1016/j.trac.2011.05.009
C. Rivet, H. Lee, A. Hirsch, S. Hamilton, H. Lu, Microfluidics for medical diagnostics and biosensors. Chem. Eng. Sci. (2011). https://doi.org/10.1016/j.ces.2010.08.015
P.K. Robinson, Enzymes: principles and biotechnological applications. Essays Biochem. (2015). https://doi.org/10.1042/BSE0590001
G.T. Rozenblum, V.G. Lopez, A.D. Vitullo, M. Radrizzani, Aptamers: Current challenges and future prospects. In Expert Opinion on Drug Discovery. 11(2), 127–135. Taylor and Francis Ltd. (2016). https://doi.org/10.1517/17460441.2016.1126244
H. SadAbadi, S. Badilescu, M. Packirisamy, R. Wüthrich, Integration of gold nanoparticles in PDMS microfluidics for lab-on-a-chip plasmonic biosensing of growth hormones. Biosens Bioelectron 44, 77–84 (2013). https://doi.org/10.1016/j.bios.2013.01.016
R. Salemmilani, B.D. Piorek, R.Y. Mirsafavi, A.W. Fountain, M. Moskovits, C.D. Meinhart, Dielectrophoretic nanoparticle aggregation for on-demand surface enhanced Raman spectroscopy analysis. Anal. Chem. 90(13), 7930–7936 (2018). https://doi.org/10.1021/acs.analchem.8b00510
B. Sharma, R.R. Frontiera, A.I. Henry, E. Ringe, R.P. Van Duyne, SERS: Materials, applications, and the future. In Materials Today (2012). https://doi.org/10.1016/S1369-7021(12)70017-2
A. Sivanesan, E. Witkowska, W. Adamkiewicz, Ł Dziewit, A. Kamińska, J. Waluk, Nanostructured silver-gold bimetallic SERS substrates for selective identification of bacteria in human blood. Analyst (2014). https://doi.org/10.1039/c3an01924a
D.A. Skoog, D.M. West, F.J. Holler, S.R. Crouch, Fundamentals of Analytical Chemistry (Ninth Edition). In Brooks/Cole Cengage Learning (2013).
G.J. Sommer, D.S. Chang, A. Jain, S.M. Langelier, J. Park, M. Rhee, F. Wang, R.I. Zeitoun, M.A. Burns, Introduction to microfluidics. In Microfluidics for Biological Applications (2009). https://doi.org/10.1007/978-0-387-09480-9_1
E.A. Songa, J.O. Okonkwo, Recent approaches to improving selectivity and sensitivity of enzyme-based biosensors for organophosphorus pesticides: A review. In Talanta (2016). https://doi.org/10.1016/j.talanta.2016.04.046
H.A. Stone, S. Kim, Microfluidics: Basic issues, applications, and challenges. In AIChE Journal (2001). https://doi.org/10.1002/aic.690470602
D.R. Thvenot, K. Toth, R.A. Durst, G.S. Wilson, Electrochemical biosensors: Recommended definitions and classification (Technical Report). Pure Appl. Chem. 71(12), 2333–2348 (1999). https://doi.org/10.1351/pac199971122333
S. Tsujimura, S. Kojima, K. Kano, T. Ikeda, M. Sato, H. Sanada, H. Omura, Novel FAD-dependent glucose dehydrogenase for a dioxygen-insensitive glucose biosensor. Biosci. Biotechnol. Biochem. 70(3), 654–659 (2006). https://doi.org/10.1271/bbb.70.654
G.K. Vertelov, A.Y. Olenin, G.V. Lisichkin, Use of nanoparticles in the electrochemical analysis of biological samples. J. Anal. Chem. 62(9), 813–824 (2007). https://doi.org/10.1134/S106193480709002X
J. Wang, Nanomaterial-based electrochemical biosensors. In Analyst (2005). https://doi.org/10.1039/b414248a
L. Wang, X. Liu, X. Hu, S. Song, C. Fan, Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers. Chem. Commun. (2006). https://doi.org/10.1039/b607448k
J. Wang, D. Xu, A.N. Kawde, R. Polsky, Metal nanoparticle-based electrochemical stripping potentiometric detection of DNA hybridization. Anal. Chem. 73(22), 5576–5581 (2001). https://doi.org/10.1021/ac0107148
H. Wei, B. Li, J. Li, E. Wang, S. Dong, Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes. Chem. Commun. (2007). https://doi.org/10.1039/b707642h
X. Weng, Y. Kang, Q. Guo, B. Peng, H. Jiang, Recent advances in thread-based microfluidics for diagnostic applications. Biosens. Bioelectron. 132(March), 171–185 (2019). https://doi.org/10.1016/j.bios.2019.03.009
G.M. Whitesides, The origins and the future of microfluidics. In Nature (2006). https://doi.org/10.1038/nature05058
Y. Wu, Y. Jiang, X. Zheng, S. Jia, Z. Zhu, B. Ren, H. Ma, Facile fabrication of microfluidic surface-enhanced raman scattering devices via lift-up lithography. Royal Society Open Science (2018). https://doi.org/10.1098/rsos.172034
H. Yamaoka, Y. Yamashita, S. Ferri, K. Sode, Site directed mutagenesis studies of FAD-dependent glucose dehydrogenase catalytic subunit of Burkholderia cepacia. Biotechnol. Lett. 30(11), 1967–1972 (2008). https://doi.org/10.1007/s10529-008-9777-3
S.M. Yoo, S.Y. Lee, Optical Biosensors for the Detection of Pathogenic Microorganisms. In Trends in Biotechnology (2016). https://doi.org/10.1016/j.tibtech.2015.09.012
L. Zheng, G. Cai, S. Wang, M. Liao, Y. Li, J. Lin, A microfluidic colorimetric biosensor for rapid detection of Escherichia coli O157:H7 using gold nanoparticle aggregation and smart phone imaging. Biosens. Bioelectron. (2019). https://doi.org/10.1016/j.bios.2018.10.006
F. Zhou, M. Lu, W. Wang, Z.-P. Bian, J.-R. Zhang, J.-J. Zhu, Electrochemical immunosensor for simultaneous detection of dual cardiac markers based on a poly(dimethylsiloxane)-gold nanoparticles composite microfluidic chip: A proof of principle. Clin Chem 56(11), 1701–1707 (2010). https://doi.org/10.1373/clinchem.2010.147256
G. Zhu, X. Yin, D. Jin, B. Zhang, Y. Gu, Y. An, Paper-based immunosensors: Current trends in the types and applied detection techniques. In TrAC - Trends in Analytical Chemistry (2019). https://doi.org/10.1016/j.trac.2018.09.027
X. Zhu, L. Shi, Electrochemistry. In Nano-Inspired Biosensors for Protein Assay with Clinical Applications (2018). https://doi.org/10.1016/B978-0-12-815053-5.00009-X
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Toppo, A.L., Jujjavarapu, S.E. New insights for integration of nano particle with microfluidic systems for sensor applications. Biomed Microdevices 24, 13 (2022). https://doi.org/10.1007/s10544-021-00598-5
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DOI: https://doi.org/10.1007/s10544-021-00598-5