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Dynamic fabrication of microfluidic systems for particles separation based on optical projection lithography

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Abstract

Microfluidic systems are widely used for applications in biology, medicine and chemistry. Particles separation by microfluidics is a scientific subject that requires ongoing research efforts. In this article, we demonstrate a micropillar-based particles separator fabricated using digital micromirror device (DMD)-based optical projection lithography from the perspectives of theory, design, simulation and experiments. Micropillars can be fabricated with customized shapes and sizes which shows high flexible and efficient. The particles separator employs the physical separation of a cylindrical array, a rectangular array, or a triangular array to separate particles. The simulation and experiment results indicate that the device with different micropillars could achieve separation of 20 and 200 μm polystyrene microspheres. Furthermore, the separation efficiency depended on flow rate and the shape of micropillars. All the results can be used to support the redesign of microfluidic structures to address particles separation needs.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Project No. 61803323), Shandong Province Higher Educational Science and Technology Program (Project No.J18KA380) and Natural Science Foundation of Shandong Province (Project No. ZR2019BF049).

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Authors and Affiliations

  1. School of Electromechanical and Automotive Engineering, Yantai University, Yantai, 264005, China

    Lujing Sun, Wenguang Yang, Honghui Chu & Rendi Yang

  2. State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China

    Haibo Yu

  3. Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110016, China

    Haibo Yu

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  1. Lujing Sun
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  2. Wenguang Yang
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  3. Honghui Chu
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  4. Rendi Yang
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Correspondence to Wenguang Yang.

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Sun, L., Yang, W., Chu, H. et al. Dynamic fabrication of microfluidic systems for particles separation based on optical projection lithography. Biomed Microdevices 22, 80 (2020). https://doi.org/10.1007/s10544-020-00535-y

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