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A novel combination of quick response code and microfluidic paper-based analytical devices for rapid and quantitative detection

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Abstract

Nowadays, there is great interest in the use of microfluidic paper-based analytical devices (μPADs) for low-cost diagnostics. In most cases, the test equipment is needed. Here we report a new type of device-independent detection method based on timer-paper-based analytical devices, which can be tested by smartphone, and its application for cholesterol detection. The Quick Response code was designed as the timer component of this device. Wax printing method was employed to print the pattern on filter paper. The color and enzyme reagents have been immobilized in the hydrophilic channel to complete the colorimetric detection for cholesterol. Under laminar flow conditions of the cellulose network, the liquid volume of detection zone has been quantified by monitoring the fluid residence time on different area of the timer-paper-based devices. The precise monitoring of detection time can promote the accuracy of colorimetric detection. This is very important for the quantitative detection of paper-based analytical devices. One significant outcome of this report is that simple and accurate timer can be used for detection process self-clocking. The factors of total detection time have been investigated. The linear range of the calibration curve was 3.0 ~ 6.0 mmol L−1, with correlation coefficient of 0.9956. With the characteristic of easy to use, low cost and accurate monitoring of detection time, this kind of timer-paper-based devices can be applied to cholesterol or other substances rapid detection.

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Acknowledgments

We gratefully acknowledge financial support from the Science and Technology Evelopment Program of Shenzhen (CKCY2017050310133507), the Science and Technology Evelopment Program of Shenzhen (JCYJ20160531184937462), the Science and Technology Transformation Project of Qinghai Province (2016-sf-128), the Clinical Pathway of Common Diseases and Standardization of Demonstration and Primary Medical Service of Altay Prefecture (201230119-2).

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Authors and Affiliations

  1. Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, 1068 Xueyuan Avenue, Shenzhen, People’s Republic of China

    Tengfei Wang, Xiaoying Wang, Xueliang Chen, Shumin Zhou & Fan You

  2. Center for Certification and Evaluation, Guangdong Food and Drug Administration, 753 dongfeng East Road, Guangdong, People’s Republic of China

    Guangning Xu

  3. Shenzhen People’s Hospital, Shenzhen, People’s Republic of China

    Wenyuan Wu

Authors
  1. Tengfei Wang
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  2. Guangning Xu
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  3. Wenyuan Wu
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  4. Xiaoying Wang
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  5. Xueliang Chen
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  6. Shumin Zhou
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  7. Fan You
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Corresponding author

Correspondence to Fan You.

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Tengfei Wang and Guangning Xu should be considered co-first authors.

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Wang, T., Xu, G., Wu, W. et al. A novel combination of quick response code and microfluidic paper-based analytical devices for rapid and quantitative detection. Biomed Microdevices 20, 79 (2018). https://doi.org/10.1007/s10544-018-0325-1

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  • DOI: https://doi.org/10.1007/s10544-018-0325-1

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