In this paper, we have fabricated 3D carbon nanofiber microelectrode arrays (MEAs) with highly reproducible and rich chemical surface areas for fast scan cyclic voltammetry (FSCV). Carbon nanofibers are created from negative photoresist by a new process called dual O2 plasma-assisted pyrolysis. The proposed approach significantly improves film adhesion and increases surface reactivity. We showcase our sensor’s compatibility with FSCV analysis by demonstrating highly sensitive and stable FSCV dopamine measurements on a prototype 4-channel array. We envision with proper surface fuctionalization the 3D carbon nanofiber MEA enable sensitive and reliable detection of multiple neurotransmitters simultaneously.
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The device was fabricated using Nano Fabrication Core (nFab) at Wayne State University. We acknowledge the staff support during the device fabrication. This work was supported by NSF CAREER Award (1055932).
Wenwen Yi and Yuanyuan Yang contributed equally to this work.
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Yi, W., Yang, Y., Hashemi, P. et al. 3D carbon nanofiber microelectrode arrays fabricated by plasma-assisted pyrolysis to enhance sensitivity and stability of real-time dopamine detection. Biomed Microdevices 18, 112 (2016). https://doi.org/10.1007/s10544-016-0136-1
- Carbon nanofiber
- Plasma-assisted pyrolysis