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Germicide wound pad with active, in situ, electrolytically produced hypochlorous acid

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Abstract

We describe a new wound dressing technology that can actively generate an inorganic germicide agent, in situ, within the wound pad. The technology provides real time control over the quantitative, spatial and temporal delivery of the germicide. The identity of the germicide is hypochlorous acid (HClO). The HClO is produced in a flexible wound pad, made of a composite of thin (micrometer scale) layers of various materials, with different electrochemical properties that enhance HClO production. Active control over the production of HClO is achieved by control of the pH and of the electric potential across the layers. The effectiveness of the Active HClO Pad (AHClOP) concept is demonstrated in a study on sterilization of E. coli in a deep wound contamination simulating gel. The performance of the AHClOP is compared with that of four commercial wound dressings. Results show that the AHClOP can sterilize throughout the gel, while the commercial dressings cannot.

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References

  • D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, M. R. Pinsky, Critical Care Medicine 29(7), 1303 (2001)

    Article  Google Scholar 

  • J. P. Banerjee, P. Das Ghatak, S. Roy, S. Khanna, E. K. Sequin, K. Bellman, B. C. Dickinson, P. Suri, V. V. Subramaniam, C. J. Chang, C. K. Sen, Plos One 9(3) (2014). doi:10.1371/journal.pone.0089239

  • J. Boateng, O. Catanzano, Journal of Pharmaceutical Sciences 104(11), 3653 (2015)

    Article  Google Scholar 

  • P. G. Bowler, B. I. Duerden, D. G. Armstrong, Clin. Microbiol. Rev. 14(2), 244 (2001)

    Article  Google Scholar 

  • B. D. Brooks, A. E. Brooks, Adv. Drug Deliv. Rev. 78, 14 (2014)

    Article  Google Scholar 

  • J. Crew, R. Varilla, T. A. Rocas, D. Debabov, L. Wang, A. Najafi, S. A. Rani, R. R. Najafi, M. Anderson, International journal of burns and trauma 2(3), 126 (2012)

    Google Scholar 

  • S. Dhivya, V. Padma, E. Santhini, BioMedicine 5(4), 24 (2015)

    Article  Google Scholar 

  • S. Guo, L. A. DiPietro, J. Dent. Res. 89(3), 219 (2010)

    Article  Google Scholar 

  • B. Healy, A. Freedman, BMJ 332(8), 838 (2006)

    Article  Google Scholar 

  • R. Hoon, S. A. Rani, R. Najafi, L. Wang, D. Debabov, Wound Repair Regen. 21(2), A27 (2013)

    Google Scholar 

  • T. C. Horan, M. Andrus, M. A. Dudeck, American Journal of Infection Control 36(5), 309 (2008)

    Article  Google Scholar 

  • D. Lapenna, D. F. Cuccurullo, General Pharmacology 27(7), 1145 (1996)

    Article  Google Scholar 

  • T. H. Leung, L. F. Zhang, J. Wang, S. Ning, S. J. Knox, S. K. Kim, Journal of Clinical Investigation 123(12), 5361 (2013)

    Article  Google Scholar 

  • S. M. McKenna, K. J. Davies, Basic Life Sci. 49, 829 (1988a)

    Google Scholar 

  • S. M. McKenna, K. J. A. Davies, Biochemical Journal 254(3), 685 (1988b)

    Article  Google Scholar 

  • N. A. Mehmood, A. Hariz, S. Templeton, N. H. Voelcker, Biomedical engineering online 14(1), 11 (2015). doi:10.1186/s12938-015-0011-y

    Article  Google Scholar 

  • V. W. L. Ng, J. M. W. Chan, H. Sardon, R. J. Ono, J. M. Garcia, Y. Y. Yang, J. L. Hedrick, Adv. Drug Deliv. Rev. 78, 46 (2014)

    Article  Google Scholar 

  • M. Phillips, N. Raju, L. Rubinsky, B. Rubinsky, Technology 3(1), 45 (2015a)

    Article  Google Scholar 

  • M. Phillips, L. Rubinsky, A. Meir, N. Raju, B. Rubinsky, Technology in cancer research & treatment 14(4), 395 (2015b)

    Article  Google Scholar 

  • M. Pourbaix, Atlas d'equilibres electrochimiques (Gauthier-Villars, 1963)

  • J. Race, Chlorination of Water (John Wiley&Sons, New York, 1918)

    Google Scholar 

  • M. Rai, A. Yadav, A. Gade, Biotechnology advances 27(1), 76 (2009)

    Article  Google Scholar 

  • W. A. Rutala, D. J. Weber, Clinical microbiology reviews 10(4), 597 (1997)

    Google Scholar 

  • J. B. Selkon, G. W. Cherry, J. M. Wilson, M. A. Hughes, Journal of wound care 15(1), 33 (2006)

    Article  Google Scholar 

  • C. K. Sen, G. M. Gordillo, S. Roy, R. Kirsner, L. Lambert, T. K. Hunt, F. Gottrup, G. C. Gurtner, M. T. Longaker, Wound Repair and Regeneration 17(6), 763 (2009)

    Article  Google Scholar 

  • J. L. Smith, A. M. Drennan, T. Rettie, W. Campbell, The British Medical Journal 2(2847), 129 (1915)

    Article  Google Scholar 

  • R. M. S. Thorn, S. W. H. Lee, G. M. Robinson, J. Greenman, D. M. Reynolds, European Journal of Clinical Microbiology & Infectious Diseases 31(5), 641 (2012)

    Article  Google Scholar 

  • S. Ud-Din, A. Sebastian, P. Giddings, J. Colthurst, S. Whiteside, J. Morris, R. Nuccitelli, C. Pullar, M. Baguneid, A. Bayat, PLoS one 10(4) (2015). doi:10.1371/journal.pone.0124502

  • L. Wang, M. Bassiri, R. Najafi, K. Najafi, J. Yang, B. Khosrovi, W. Hwong, E. Barati, B. Belisle, C. Celeri, M. C. Robson, Journal of Burns and Wounds 6, e5 (2007)

    Google Scholar 

  • S. J. Weiss, New England Journal of Medicine. 320(6), 365 (1989)

    Article  Google Scholar 

  • C. C. Winterbourn, Toxicology 181, 223 (2002)

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. RM2 Technologies LTD., 31 Pegasus Drive, Coto De Caza, CA, 92679, USA

    L. Rubinsky, B. Patrick, P. Mikus & B. Rubinsky

  2. Exponent, Inc., 149 Commonwealth Dr., Menlo Park, CA, 94025, USA

    B. Patrick

  3. Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, 94720, USA

    B. Rubinsky

Authors
  1. L. Rubinsky
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  2. B. Patrick
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  3. P. Mikus
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  4. B. Rubinsky
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Correspondence to B. Rubinsky.

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Conflict of interest

The authors declare a financial interest in RM2 Technologies LTD, a company whose goal is developing the AHClOP technology.

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Rubinsky, L., Patrick, B., Mikus, P. et al. Germicide wound pad with active, in situ, electrolytically produced hypochlorous acid. Biomed Microdevices 18, 26 (2016). https://doi.org/10.1007/s10544-016-0052-4

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  • DOI: https://doi.org/10.1007/s10544-016-0052-4

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