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Electrochemical and in vitro neuronal recording characteristics of multi-electrode arrays surface-modified with electro-co-deposited gold-platinum nanoparticles

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Abstract

In order to complement the high impedance electrical property of gold nanoparticles (Au NPs) we have performed electro-co-deposition of gold-platinum nanoparticles (Au-Pt NPs) onto the Au multi-electrode array (MEA) and modified the Au-Pt NPs surface with cell adhesive poly-D-lysine via thiol chemistry based covalent binding. The Au-Pt NPs were analyzed to have bimetallic nature not the mixture of Au NPs and Pt NPs by X-ray diffraction analysis and to have impedance value (4.0 × 104 Ω (at 1 kHz)) comparable to that of Pt NPs. The performance of Au-Pt NP-modified MEAs was also checked in relation to neuronal signal recording. The noise level in Au-Pt NP-modified MEAs was lower than in that of Au NP-modified MEA.

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Acknowledgments

This study was supported by the Pioneer Research Center Program through National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (2012-0009464) and by the ETRI (16ZE1160).

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Authors and Affiliations

  1. Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea

    Yong Hee Kim, Ah Young Kim, Gook Hwa Kim, Young Hwan Han, Myung-Ae Chung & Sang-Don Jung

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  1. Yong Hee Kim
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  2. Ah Young Kim
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  3. Gook Hwa Kim
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  4. Young Hwan Han
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  5. Myung-Ae Chung
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  6. Sang-Don Jung
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Correspondence to Sang-Don Jung.

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Kim, Y.H., Kim, A.Y., Kim, G.H. et al. Electrochemical and in vitro neuronal recording characteristics of multi-electrode arrays surface-modified with electro-co-deposited gold-platinum nanoparticles. Biomed Microdevices 18, 14 (2016). https://doi.org/10.1007/s10544-016-0044-4

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  • DOI: https://doi.org/10.1007/s10544-016-0044-4

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