Abstract
We describe an integration strategy for arbitrary sensors intended to be used as biosensors in biomedical or bioanalytical applications. For such devices ease of handling (by a potential end user) as well as strict disposable usage are of importance. Firstly we describe a generic array compatible polymer sensor housing with an effective sample volume of 1.55 μl. This housing leaves the sensitive surface of the sensor accessible for the application of biosensing layers even after the embedding. In a second step we show how this sensor housing can be used in combination with a passive disposable microfluidic chip to set up arbitrary 8-fold sensor arrays and how such a system can be complemented with an indirect microfluidic flow injection analysis (FIA) system. This system is designed in a way that it strictly separates between disposable and reusable components- by introducing tetradecane as an intermediate liquid. This results in a sensor system compatible with the demands of most biomedical applications. Comparative measurements between a classical macroscopic FIA system and this integrated indirect microfluidic system are presented. We use a surface acoustic wave (SAW) sensor as an exemplary detector in this work.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
F. Bender, K. Länge, A. Voigt, M. Rapp, Anal Chem 76, 3837–3840 (2004)
R. Bogue, Sens Rev 25, 180–184 (2005)
T. Cass, C. Toumazou, Foresight—infectious diseases: preparing for the future, 1–30 (2006)
M. Cole, J.W. Gardner, I.L. Leonte, G. Sehra, H.S. Noh et al. 2005 IEEE Sensors (IEEE Cat. No.05CH37665C). IEEE. 2005, 4 (2005)
L.A. Francis, J.M. Friedt, C. Bartic, A. Campitelli, SPIE-Int Soc Opt Eng Proc SPIE - Int Soc Opt Eng 5455, 353–363 (2004)
H. Fu-Chun, L. Chia-Sheng, L. Gwo-Bin, Electrophoresis 27, 3297–3305 (2006)
J. Giboz, T. Copponnex, P. Mele, J Micromech Microeng 17, R96–R109 (2007)
T.M.A. Gronewold, S. Glass, E. Quandt, A. Famulok, Biosens Bioelectron 20, 2044–2052 (2005)
P.M. Günther, F. Möller, T. Henkel, J.M. Köhler, G.A. Groß, Chem Eng Technol 28, 520–527 (2005)
L. Gwo-Bin, C.J. Huang, C. Yi-Hsin, W. Chih-Hao, C. Tse-Chuan, Sens Actuators B 122, 461–468 (2007)
M. Heckele, W.K. Schomburg, J Micromech Microeng 14, R1–R14 (2004)
M. Kim, S.H. Han, Y.B. Shin, B.H. Chung, BioChip J 1, 81–89 (2007)
K. Länge, F. Bender, A. Voigt, H. Gao, M. Rapp, Anal Chem 75, 5561–5566 (2003)
K. Länge, G. Blaess, A. Voigt, R. Götzen, M. Rapp, Biosens Bioelectron 22, 227–232 (2006)
K. Länge, S. Grimm, M. Rapp, Sens Actuators B 125, 441–446 (2007)
K. Länge, B.E. Rapp, M. Rapp, Anal Bioanal Chem 391, 1509–1519 (2008)
J.H.T. Luong, K.B. Male, J.D. Glennon, Biotechnol Adv 26, 492–500 (2008)
K. Martin, T. Henkel, V. Baier, A. Grodrian, T. Schon et al., Lab Chip 3, 202–207 (2003)
B. Pejcic, R. De Marco, Electrochim Acta 51, 6217–6229 (2006)
B.E. Rapp, L. Carneiro, K. Länge, M. Rapp, Lab Chip 9, 354–356 (2009)
B.E. Rapp, F.J. Gruhl, K. Länge, Anal. Bioanal. Chem. 1–10 (2010)
J. Reibel, S. Stier, A. Voigt, M. Rapp, Anal Chem 70, 5190–5197 (1998)
J. Růžička, E.H. Hansen, edn, Wiley (1981)
E.B. van Akker, M. Bos, W.E. van der Linden, Anal Chim Acta 373, 227–239 (1998)
C.-H. Wang, G.-B. Lee, Biosens Bioelectron 21, 419–425 (2005)
Acknowledgement
The authors would like to thank Christian Alexander Wojek for his constant help and advice with software and hardware related issues.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rapp, B.E., Schickling, B., Prokop, J. et al. Design and integration of a generic disposable array-compatible sensor housing into an integrated disposable indirect microfluidic flow injection analysis system. Biomed Microdevices 13, 909–922 (2011). https://doi.org/10.1007/s10544-011-9560-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10544-011-9560-4