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Design and optimization of non-clogging counter-flow microconcentrator for enriching epidermoid cervical carcinoma cells

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Abstract

Clogging failure is common for microfilters in living cells concentration; for instance, the CaSki Cell-lines (Epidermoid cervical carcinoma cells) utilizing the flat membrane structure. In order to avoid the clogging, counter-flow concentration units with turbine blade-like micropillar are proposed in microconcentrator design. Due to the unusual geometrical-profiles and extraordinary microfluidic performance, the cells blocking does not occur even at permeate entrances. A counter-flow microconcentrator was designed, with both processing layer and collecting layer arranged in terms of the fractal based honeycomb structure. The device was optimized by coupling Artificial Neuron Network (ANN) and Computational Fluid Dynamics (CFD). The excellent concentration ratio of a final microconcentrator was presented in numerical results.

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Acknowledgments

This research work is supported by Norwegian Government NFR Funds (Project POCNAD), Natural Science Foundation of Fujian Province, China (No.2007 J0032), and National Natural Science Foundation of China (No.50406019). The authors would like to thank Ph.D Anja Gulliksen, Ph.D Lars Soli, and Ph.D Hanne Skomedal in NorChip AS for their great technical contributions. We also would like to thank Lars Eric Roseng, Matteo J Kapiris, Paolo Calabrese and Eirik Bentzen Egeland in Vestfold University College for their contributions.

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Authors and Affiliations

  1. I.M.S.T./TekMar, Norwegian Center of Expertise on Micro- and Nanotechnology, Vestfold University College, Tønsberg, N-3103, Norway

    Nhut Tran-Minh, Tao Dong, Qianhua Su, Zhaochu Yang, Henrik Jakobsen & Frank Karlsen

  2. NorChip A.S., Industriveien 8, N-3490, Klokkarstra, Norway

    Frank Karlsen

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  1. Nhut Tran-Minh
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  2. Tao Dong
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  3. Qianhua Su
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  4. Zhaochu Yang
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  5. Henrik Jakobsen
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  6. Frank Karlsen
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Correspondence to Tao Dong.

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Tran-Minh, N., Dong, T., Su, Q. et al. Design and optimization of non-clogging counter-flow microconcentrator for enriching epidermoid cervical carcinoma cells. Biomed Microdevices 13, 179–190 (2011). https://doi.org/10.1007/s10544-010-9483-5

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