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Microfluidic particle sorting utilizing inertial lift force

Biomedical Microdevices volume 13, pages 97–105 (2011)Cite this article

Abstract

A simple passive microfluidic device that continuously separates microparticles is presented. Its development is motivated by the need for specific size micro perfluorocarbon (PFC) droplets to be used for a novel gas embolotherapy method. The device consists of a rectangular channel in which inertial lift forces are utilized to separate particles in lateral distance. At the entrance of the channel, particles are introduced at the center by focusing the flow from a center channel with flow from two side channels. Downstream, large particles will occupy a lateral equilibrium position in shorter axial distance than small particles. At the exit of the channel, flow containing large particles is separated from flow containing small particles. It is shown that 10.2-μm diameter microspheres can be separated from 3.0-μm diameter microspheres with a separation efficiency of 69–78% and a throughput in the order of 2 ·104 particles per minute. Computational Fluid Dynamics (CFD) calculations were done to calculate flow fields and verify theoretical particle trajectories. Theory underlying this research shows that higher separation efficiencies for very specific diameter cut-off are possible. This microfluidic channel design has a simple structure and can operate without external forces which makes it feasible for lab-on-a-chip (LOC) applications.

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Acknowledgements

This work was supported by NIH grant RO1 EB006476.

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Affiliations

  1. University of Michigan, Ann Arbor, MI, USA

    Harm A. Nieuwstadt, Robinson Seda, David S. Li, J. Brian Fowlkes & Joseph L. Bull

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  1. Harm A. Nieuwstadt
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  2. Robinson Seda
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  3. David S. Li
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  4. J. Brian Fowlkes
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  5. Joseph L. Bull
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Correspondence to Joseph L. Bull.

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Nieuwstadt, H.A., Seda, R., Li, D.S. et al. Microfluidic particle sorting utilizing inertial lift force. Biomed Microdevices 13, 97–105 (2011). https://doi.org/10.1007/s10544-010-9474-6

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  • DOI: https://doi.org/10.1007/s10544-010-9474-6

Keywords

  • Gas embolotherapy
  • Cardiovascular
  • Cancer
  • Perfluorocarbon
  • Microcirculation