Biomedical Microdevices

, Volume 12, Issue 5, pp 875–886 | Cite as

Combined micro and macro additive manufacturing of a swirling flow coaxial phacoemulsifier sleeve with internal micro-vanes

  • Jae-Won Choi
  • Masaki Yamashita
  • Jun Sakakibara
  • Yuichi Kaji
  • Tetsuro Oshika
  • Ryan B. Wicker
Article

Abstract

Microstereolithography (µSL) technology can fabricate complex, three-dimensional (3D) microstructures, although µSL has difficulty producing macrostructures with micro-scale features. There are potentially many applications where 3D micro-features can benefit the overall function of the macrostructure. One such application involves a medical device called a coaxial phacoemulsifier where the tip of the phacoemulsifier is inserted into the eye through a relatively small incision and used to break the lens apart while removing the lens pieces and associated fluid from the eye through a small tube. In order to maintain the eye at a constant pressure, the phacoemulsifier also includes an irrigation solution that is injected into the eye during the procedure through a coaxial sleeve. It has been reported, however, that the impinging flow from the irrigation solution on the corneal endothelial cells in the inner eye can damage these cells during the procedure. As a result, a method for reducing the impinging flow velocities and the resulting shear stresses on the endothelial cells during this procedure was explored, including the design and development of a complex, 3D micro-vane within the sleeve. The micro-vane introduces swirl into the irrigation solution, producing a flow with rapidly dissipating flow velocities. Fabrication of the sleeve and fitting could not be accomplished using µSL alone, and thus, a two-part design was accomplished where a sleeve with the micro-vane was fabricated with µSL and a threaded fitting used to attach the sleeve to the phacoemulsifier was fabricated using an Objet Eden 333 rapid prototyping machine. The new combined device was tested within a water container using particle image velocimetry, and the results showed successful swirling flow with an ejection of the irrigation fluid through the micro-vane in three different radial directions corresponding to the three micro-vanes. As expected, the sleeve produced a swirling flow with rapidly dissipating streamwise flow velocities where the maximum measured streamwise flow velocities using the micro-vane were lower than those without the micro-vane by 2 mm from the tip where they remained at ∼70% of those produced by the conventional sleeve as the flow continued to develop. It is believed that this new device will reduce damage to endothelial cells during cataract surgery and significantly improve patient outcomes from this procedure. This unique application demonstrates the utility of combining µSL with a macro rapid prototyping technology for fabricating a real macro-scale device with functional, 3D micro-scale features that would be difficult and costly to fabricate using alternative manufacturing methods.

Keywords

Phacoemulsification Cataract surgery Swirl Microstereolithography Micro fabrication 

References

  1. A. Bertsch, S. Zissi, J.Y. Jézéquel, S. Corbel, J.C. André, Microsyst. Technol. 3, 42–47 (1997)CrossRefGoogle Scholar
  2. A. Bertsch, S. Zissi, J.Y. Jézéquel, S. Corbel, J.C. André, Microstereolithography: concepts and applications. Proc. 8th IEEE Int. Conf. Emerging Technologies and Factory Automation, 289–98 (2001)Google Scholar
  3. A. Bertsch, S. Jiguet, P. Renaud, J. Micromechanics Microengineering 14, 197–203 (2004)CrossRefGoogle Scholar
  4. P.S. Binder, H. Sternberg, M.G. Wickham, D.M. Worthen, Am. J. Ophthalmol. 82, 48–54 (1976)Google Scholar
  5. C. Born, Z. Zhang, M. Al-Rubeai, C.R. Thomas, Biotechnol. Bioeng. 40, 1004–1010 (1992)CrossRefGoogle Scholar
  6. J.W. Choi, Y.M. Ha, S.H. Lee, K.H. Choi, J. Mech. Sci. Technol. 20, 2094–2104 (2006)CrossRefGoogle Scholar
  7. J.W. Choi, R.B. Wicker, S.H. Cho, C.S. Ha, S.H. Lee, Rapid Prototyping J. 15, 59–70 (2009a)CrossRefGoogle Scholar
  8. J.W. Choi, R.B. Wicker, S.H. Lee, K.H. Choi, C.S. Ha, I. Chung, J. Mater. Process. Technol. 209, 5494–5503 (2009b)CrossRefGoogle Scholar
  9. J.W. Choi, E. MacDonald, R.B. Wicker, Int. J. Adv. Manuf. Technol. 49, 543–551 (2010)Google Scholar
  10. DSM Somos, ProtoThermTM 12120—Product Data Sheet (New Castle, DE, June 2004) www.dsmsomos.com
  11. A. Foster, Comm. Eye Health 13, 17–19 (2000)Google Scholar
  12. D. Gajjar, M.R. Praveen, A.R. Vasavada, D. Pandita, V.A. Vasavada, D.B. Patel, K. Johar, S. Raj, J. Cataract Refract. Surg. 33, 2129–2134 (2007)CrossRefGoogle Scholar
  13. Y.M. Ha, J.W. Choi, S.H. Lee, J. Mech. Sci. Technol. 22, 514–521 (2008)CrossRefGoogle Scholar
  14. L.H. Han, G. Mapili, S. Chen, K. Roy, J. Manuf. Sci. Eng.-Trans. ASME 130, 021005-1-4 (2008)Google Scholar
  15. K. Hayashi, H. Hayashi, F. Nakao, F. Hayashi, J. Cataract Refract. Surg. 22, 1079–1084 (1996)Google Scholar
  16. K. Ikuta, K. Kirowatari, Real three dimensional micro fabrication using stereo lithography and metal molding. Proc. Int. Conf. MEMS. 42–47 (1993)Google Scholar
  17. P.F. Jacobs, Rapid Prototyping and Manufacturing: Fundamentals of Stereolithography (McGraw-Hills, New York, 1993)Google Scholar
  18. A.M. Joussen, U. Barth, H. Çubuk, H.R. Koch, J. Cataract Refract. Surg. 26, 392–397 (2000)CrossRefGoogle Scholar
  19. Y. Kaji, T. Oshika, T. Usui, J. Sakakibara, Cornea 24, S55–S58 (2005)CrossRefGoogle Scholar
  20. S. Khalil, W. Sun, Mater. Sci. Eng. C-Biomimetic Supramol. Syst. 27, 469–478 (2007)Google Scholar
  21. S.J. Lee, H.W. Kang, T.Y. Kang, B. Kim, G. Lim, J.W. Rhie, D.W. Cho, J. Micromechanics Microengineering 17, 147–153 (2007)CrossRefGoogle Scholar
  22. S.J. Lee, H.W. Kang, J.K. Park, J.W. Rhie, S.K. Hahn, D.W. Cho, Biomed. Microdevices 10, 233–241 (2008)CrossRefGoogle Scholar
  23. K.M. Lee, H.G. Kwon, C.K. Joo, J. Cataract Refract. Surg. 35, 874–880 (2009)CrossRefGoogle Scholar
  24. A.S. Limaye, D.W. Rosen, Rapid Prototyping J. 12, 283–291 (2006)CrossRefGoogle Scholar
  25. A.S. Limaye, D.W. Rosen, Rapid Prototyping J. 13, 76–84 (2007)CrossRefGoogle Scholar
  26. M.W. Miller, D.L. Miller, A.A. Brayman, Ultrasound Med. Biol. 22, 1131–1154 (1996)CrossRefGoogle Scholar
  27. P.D. O’Brien, P. Fitzpatrick, D.J. Kilmartin, S. Beatty, J. Cataract Refract. Surg. 30, 839–843 (2004)CrossRefGoogle Scholar
  28. R.H. Osher, V.P. Injev, J. Cataract Refract. Surg. 33, 401–407 (2007)CrossRefGoogle Scholar
  29. I.B. Park, Y.M. Ha, S.H. Lee, Int. J. Adv. Manuf. Technol. 46, 151–161 (2010) Published online: 07 May 2009, doi:10.1007/s00170-009-2065-0 Google Scholar
  30. F.M. Polack, A. Sugar, Invest. Ophthalmol. 15, 458–469 (1976)Google Scholar
  31. P. Regenfuss, A. Streek, L. Hartwig, S. Klötzer, Th Brabant, M. Horn, R. Ebert, H. Exner, Rapid Prototyping J. 13, 204–212 (2007)CrossRefGoogle Scholar
  32. J. Sakakibara, M. Nakagawa, M. Yoshida, Exp. Fluids 36, 282–293 (2004)CrossRefGoogle Scholar
  33. R.F. Steinert, M.E. Schafer, J. Cataract Refract. Surg. 32, 284–287 (2006)CrossRefGoogle Scholar
  34. C. Sun, X. Zhang, J. Appl. Phys. 92, 4796–4802 (2002)CrossRefGoogle Scholar
  35. C. Sun, N. Fang, D.M. Wu, X. Zhang, Sens. Actuator, A, Phys. 121, 113–120 (2005)CrossRefGoogle Scholar
  36. O. Thoumine, T. Znegler, P.R. Girard, R.M. Nerem, Exp. Cell Res. 219, 427–441 (1995)CrossRefGoogle Scholar
  37. M. Topaz, M. Motiei, E. Assia, Ultrasound Med. Biol. 28, 775–784 (2002)CrossRefGoogle Scholar
  38. V.K. Varadan, X. Jiang, V.V. Varadan, Microstereolithography and Other Fabrication Techniques for 3D MEMS (Wiley, West Sussex, 2001)Google Scholar
  39. R.B. Wicker, J.K. Eaton, Int. J. Multiph. Flow 27, 949–970 (2001)MATHCrossRefGoogle Scholar
  40. D. Wu, Micro fabrication of 3D structure and characterization of molecular machines, Ph. D. Dissertation, The University of California at Los Angeles, 33 (2005)Google Scholar
  41. S. Zissi, A. Bertsch, J.Y. Jézéquel, S. Corbel, D.J. Lougnot, J.C. André, Microsyst. Technol. 2, 97–102 (1996)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jae-Won Choi
    • 1
    • 2
  • Masaki Yamashita
    • 3
  • Jun Sakakibara
    • 3
  • Yuichi Kaji
    • 4
  • Tetsuro Oshika
    • 4
  • Ryan B. Wicker
    • 1
    • 2
  1. 1.W.M. Keck Center for 3D InnovationThe University of Texas at El PasoEl PasoUSA
  2. 2.Department of Mechanical EngineeringThe University of Texas at El PasoEl PasoUSA
  3. 3.Department of Engineering Mechanics and EnergyUniversity of TsukubaTsukuba, IbarakiJapan
  4. 4.Department of Ophthalmology, Institute of Clinical MedicineUniversity of TsukubaTsukuba, IbarakiJapan

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