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Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip

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Abstract

This paper describes a novel powerful noncontact actuation of a magnetically driven microtool (MMT), achieved by magnetization of the MMT and focusing of the magnetic field in a microfluidic chip for particle sorting. The following are the highlights of this study: (1) an MMT was successfully fabricated from a mixture of neodymium powder and polydimethylsiloxane; the MMT was magnetized such that it acted as an elastic micromagnet with a magnetic flux density that increased by about 100 times after magnetization, and (2) a pair of sharp magnetic needles was fabricated adjacent to a microchannel in a chip by electroplating, in order to focus the magnetic flux density generated by the electromagnetic coils below the biochip; these needles contribute to miniaturization of an actuation module that would enable the integration of multiple functions in the limited area of a chip. FEM analysis of the magnetic flux density around the MMT showed that the magnetic flux density in the setup with the magnetic needles was around 8 times better than that in the setup without the needles. By magnetization, the drive frequency of the MMT improved by about 10 times—from 18 Hz to 180 Hz. We successfully demonstrated the separation of copolymer beads of a particular size in a chip by image sensing.

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Acknowledgement

This work was financially supported by the Research and Development Program for New Bio-industry Initiatives and the Ministry of Education, Culture, Sports, Science and Technology, and by Grants-in-Aid for Scientific Research (17040017 & 19016004). The authors would like to thank Prof. S. Sugimoto, Tohoku University, for allowing us to use the magnetization facilities.

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Authors and Affiliations

  1. Japan Science & Technology Agency (JST), PRESTO, Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Aichi-ken, Japan

    Yoko Yamanishi

  2. Department of Bioengineering and Robotics, Tohoku University, 6-6-01, Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi-ken, 980-8579, Japan

    Shinya Sakuma & Kazuhisa Onda

  3. Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Aichi-ken, Japan

    Fumihito Arai

Authors
  1. Yoko Yamanishi
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  2. Shinya Sakuma
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  3. Kazuhisa Onda
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  4. Fumihito Arai
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Correspondence to Yoko Yamanishi.

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Yamanishi, Y., Sakuma, S., Onda, K. et al. Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip. Biomed Microdevices 12, 745–752 (2010). https://doi.org/10.1007/s10544-010-9428-z

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  • DOI: https://doi.org/10.1007/s10544-010-9428-z

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