Biomedical Microdevices

, Volume 12, Issue 3, pp 435–442 | Cite as

Development of a protein sensing device utilizing interactions between polyaniline and a polymer acid dopant

  • Carolyn L. Bayer
  • Alper A. Konuk
  • Nicholas A. Peppas


Human disease processes are often characterized by a deviation from the normal physiological concentration of critical biomarkers. The detection of disease biomarkers requires the development of novel sensing methods which are sensitive, specific, efficient and low-cost. To address this need, the ability of a device, which incorporates a film of polymer acid doped polyaniline, to respond to proteins at physiological pH and ionic strength was assessed. The conductive polymer was found to respond by changing conductivity in the presence of biomolecules, demonstrating a direct chemical to electronic transduction method. In future work, specificity can be incorporated into the system by integrating the conductive polymer with a protein selective film. The demonstration of a conductive polymer which is responsive to proteins at physiological conditions is a step towards the integration of these materials into implantable sensing systems.


Conductive polymers Polyaniline Biosensor Bovine serum albumin Lysozyme 





poly(2-acrylamido-2-methylpropanesulfonic acid)




bovine serum albumin




ammonium persulfate


phosphate buffered solution


sodium chloride


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Carolyn L. Bayer
    • 1
  • Alper A. Konuk
    • 2
  • Nicholas A. Peppas
    • 1
    • 2
    • 3
  1. 1.Department of Biomedical Engineering, Center on Biomaterials, Drug Delivery, Bionanotechnology and Molecular RecognitionThe University of Texas at AustinAustinUSA
  2. 2.Department of Chemical Engineering, Center on Biomaterials, Drug Delivery, Bionanotechnology and Molecular RecognitionThe University of Texas at AustinAustinUSA
  3. 3.Department of Pharmaceutics, Center on Biomaterials, Drug Delivery, Bionanotechnology and Molecular RecognitionThe University of Texas at AustinAustinUSA

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