Abstract
A drug-delivery microdevice integrating pH-responsive nano-hydrogel particles functioning as intelligent nano valves is described. The polymeric microdevices are monolithic without requiring peripheral control hardware or additional components for controlling drug-release rates. pH-responsive nanoparticles were synthesized and embedded into a composite membrane. The resulting pH-responsive composite membranes were integrated with PDMS micro reservoirs via a room-temperature transfer bonding technique to form the proof-of-concept microdevices. In vitro release characterization of the microdevices was conducted in which the release rate of Vitamin B12 (VB12) as a model drug increased dramatically when the local pH value was decreased from 7.4 to 4. This device concept can serve as a platform technology for intelligent drug delivery in response to various in vivo environmental signals.
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This work was supported by a NSERC-CIHR Collaborative Health Research Grant (CHRP#482996).
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Authors Jian Chen and Michael Chu contributed equally.
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Chen, J., Chu, M., Koulajian, K. et al. A monolithic polymeric microdevice for pH-responsive drug delivery. Biomed Microdevices 11, 1251–1257 (2009). https://doi.org/10.1007/s10544-009-9344-2
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DOI: https://doi.org/10.1007/s10544-009-9344-2