Biomedical Microdevices

, Volume 11, Issue 3, pp 579–583

Hybridization of localized surface plasmon resonance-based Au–Ag nanoparticles


DOI: 10.1007/s10544-008-9267-3

Cite this article as:
Zhu, S. & Fu, Y. Biomed Microdevices (2009) 11: 579. doi:10.1007/s10544-008-9267-3


The hybrid Au–Ag triangular nanoparticles were proposed for the purpose of biosensing. To construct the nanoparticles, an Au thin film was deposited on top of the Ag nanoparticles supported with glass substrate. The hybrid nanoparticles can prevent oxidation of the pure Ag nanoparticles due to the Au protective layer caped on the Ag nanoparticles. The hybrid nanoparticles were designed using finite-difference and time-domain algorithm. Extinction spectra of the hybrid nanoparticles excited by visible light beam with plane wave were calculated, and the corresponding electric fields at peak position of the extinction spectra were expressed also. It is clear that the hybrid nanoparticles can excite the localized surface plasmon resonance wave which can be used to detect biomolecules. As an application example, we presented relevant detection results by means of using protein A to covalently link surface of the hybrid nanoparticles. Refractive index sensitivity of the hybrid nanoparticles was derived through both computational numerical calculation and experimental detection. Both the calculated and the experimental extinction spectra show that the hybrid Au–Ag nanoparticles are useful for detecting the biomolecules.


Hybrid Au–Ag nanoparticles Nano-biosensor LSPR Spectroscopy 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Photonics Centre, School of Electronic and Electrical EngineeringNanyang Technological UniversitySingaporeSingapore
  2. 2.School of Physical ElectronicsUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China

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