Abstract
Monitoring of ischemia in living tissues is a field of increasing interest in many clinical settings. In this work we report for the first time anywhere the development of needle-shaped, minimally-invasive impedance probes based on silicon carbide (SiC) substrates. An in-vitro comparison of these new devices with Si-based impedance probes demonstrates that their effective operation range extends up to the 100 kHz range, thus allowing a wide-spectrum multi-frequency analysis of impedance modulus and phase angle. Furthermore, we show that, when applied to in-vivo settings, this kind of analysis yields to an accurate monitoring of ischemia, while making possible the application of more robust mathematical methods for the study of impedance in living tissues.
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References
W.J. Choyke and H. Matsunamiand G. Pensl, Silicon Carbide: Recent Major Advances. Berlin: Springer Verlag, (2003).
K.S. Cole, Quant. Biol. 110, (1940).
W.R. Dolbier Jr and W.F Beach, Journal of Fluorine Chemestry 122, 97 (2003).
M. Genescà, A. Ivorra, A. Sola, L. Palacios, R. Villa, and G. Hotter, Procceedings of the XII Inter. Conf. Elec. Bio. and V Elec. Imp, Gdnaks, Poland. 1, 127 (2004).
M. Genescà, A. Ivorra, A. Sola, L. Palacios, J.-M. Goujon, T. Hauet, R. Villa, J. Aguilo, and G. Hotter, Biosensors and Bioelectronics 20, 1866 (2005).
L.A. Geddes in Electrodes and the measurements of bioelectric events. Wiley Interscience, New York (1972).
E. Gersing Biomedizinische Technik 36(1/3), 6 (1991).
E. Gersing Bioelectrochem. Bioenerg. 45, 145 (1998).
S. Grimnes and O.G. Martinsenin Bioimpedance and Bioelectricity Basics. Academic Press (2000).
D. Haemmerich, R. Ozkan, S. Tungjitkusolmun, J.Z. Tsai and D.M. MahviS.T. Staelin, and J.G. Webster, Med. Biol Eng Comput. 40, 29 (2002).
A. Ivorra, R. Gomez, N. Noguera, R. Villa and A. SolaL. Palacios, G. Hotter, and J. Aguilo, Biosens. Biolectron. 19, 391 (2003).
A. Ivorra M. Genescà, A. Sola, L. Palacios, R. Villa, G. Hotter, and J. Aguiló, Physiol. Meas. 26, S165 (2005).
G. Kotzar, M. Freas, P. Abel, A. Fleischman and S. RoyC. Zorman, J.M. Moran, and J. Melzak, Biomaterials 23, 2737 (2002).
X. Li, X. Wang, R. Bondokov and J. Morris, Y.H. An., and T.S. Sudarshan, Journal of Biomedical Materials. Research Part B: Applied Biomaterials 72B(2), 353 (2004).
H.E. Möller, A. Gaupp, K.-H. Dietl, B. Buchholz, and T. Vestring, Magnetic Resonance Imaging 18(6), 743 (2000).
P.G. Neudeck in Silicon carbide electronic devices. Encyclopedia of Materials: Science and Technology. ISBN: 0-08-0431526. 8508-8519.
V. Raicu and T. Saibaraand A. Irimajiri, Phys. Med. Biol. 45, 1397 (2000).
A.J. Rosenbloom, D.M. Sipe, Y. Shishkin, Y. Ke and R.P. Devatyand W.J. Choyke, Biomedical Microdevice 6(4), 261 (2004).
A. Sola, L. Palacios, J. Lopez-Marti, A. Ivorra, N. Noguera, R. Gomez, R. Villa, J. Aguilo, and G. Hotter, Transplantation 75(6), 744 (2003).
B.M. Stubenitsky, M.H. Booster, A.P. Nederstigt, J.K. Kievit and R.W.A. Jacobsand G. Kootstra, Transplant. Int. 12, 83 (1999).
T.I. Tonnessen and G. KvarsteinActa Anasthesiol Scand 40, 510 (1996).
K.G. Warner, M. Josa, M.D. Butler, P.C. Gherardi and S.N. AssousaA.J. Saad, S. Siouffi, E.M. Barsamian, and S.F. Khuri, Ann Thorac Surg 45(1), 75 (1988).
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Gómez, R., Ivorra, A., Villa, R. et al. A SiC microdevice for the minimally invasive monitoring of ischemia in living tissues. Biomed Microdevices 8, 43–49 (2006). https://doi.org/10.1007/s10544-006-6381-y
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DOI: https://doi.org/10.1007/s10544-006-6381-y