Abstract
A kinetic model for the membrane Ca2+-ATPase is considered. The catalytic cycle in the model is extended by enzyme auto-inhibition and by oscillatory calcium influx. It is shown that the conductive enzyme activity can be registered as damped or sustained Ca2+ pulses similar to observed experimentally. It is shown that frequency variations in Ca2+ oscillatory influx induce changes of pulsating enzyme activity. Encoding is observed for the signal frequency into a number of fixed levels of sustained pulses in the enzyme activity. At certain calcium signal frequencies, the calculated Ca2+-ATPase conductivity demonstrates chaotic multi-level pulses, similar to those observed experimentally.
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Translated from Biokhimiya, Vol. 70, No. 4, 2005, pp. 539–544.
Original Russian Text Copyright © 2005 by Goldstein, Mayevsky, Zakrjevskaya.
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Goldstein, B.N., Mayevsky, A.A. & Zakrjevskaya, D.T. Influence of Ca2+ Oscillatory Influx on Membrane Ca2+-ATPase Activity: a Kinetic Model. Biochemistry (Moscow) 70, 445–448 (2005). https://doi.org/10.1007/s10541-005-0135-y
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DOI: https://doi.org/10.1007/s10541-005-0135-y