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Mannose-6-phosphate/Insulin-like Growth Factor II Receptor Expression and Tumor Development

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Bioscience Reports

Abstract

The mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR) is a multi-functional transmembrane glycoprotein whose major function is to bind and transport M6P-bearing glycoproteins from the trans-Golgi network or the cell surface to lysosomes. The cell surface M6P/IGF-IIR also bind and internalizes the insulin-like growth factor II. The receptor gene is considered a « candidate » tumor suppressor gene. The phenotypic consequences of loss of M6P/IGF-IIR through somatic mutation are potentially very complex since M6P/IGF-IIR has a number of roles in cellular physiology. Loss of function mutations in M6P/IGF-IIR gene could contribute to multi-step carcinogenesis. In the light of the multi-functional cellular potential roles of the M6P/IGF-IIR the purpose of this review is to highlight some recent data concerning its normal functions and the potential role of its loss in tumor pathophysiology with the aim to try to clarify the possible underlying mechanisms of its involvement in tumor development.

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Abbreviations

M6P/IGF-IIR:

mannose-6-phosphate/insulin-like growth factor II receptor

IGF-IR:

insulin-like growth factor I receptor

RA:

retinoic acid

M6P:

mannose-6-phosphate

IGF-I:

insulin-like growth factor I

IGF-II:

insulin-like growth factor II

TGF-β :

transforming growth factor-β

uPAR:

urokinase-type plasminogen activator receptor

LOH:

loss of heterozygosity

HCC:

hepatocellular carcinoma

MI:

microsatellite instability

LIF:

leukemia inhibitory factor

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Acknowledgments

The author would like to thank Pr. M. Monsigny and Dr. AC Roche for critical reading of manuscript and support.

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  1. Vectorologie et trafic Intracellulaire, Centre de Biophysique Moléculaire, UPR no 4301 du CNRS, Rue Charles Sadron, 45071, Orleans Cedex 2, France

    Eric Hébert

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Hébert, E. Mannose-6-phosphate/Insulin-like Growth Factor II Receptor Expression and Tumor Development. Biosci Rep 26, 7–17 (2006). https://doi.org/10.1007/s10540-006-9002-3

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