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Adaptive Activation of Thyroid Hormone and Energy Expenditure

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The mechanisms by which thyroid hormone accelerates energy expenditure are poorly understood. In the brown adipose tissue (BAT), activation of thyroid hormone by type 2 iodothyronine deiodinase (D2) has been known to play a role in adaptive energy expenditure during cold exposure in human newborns and other small mammals. Although BAT is not present in significant amounts in normal adult humans, recent studies have found substantial amounts of D2 in skeletal muscle, a metabolically relevant tissue in humans. This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure.

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Authors and Affiliations

  1. Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, HIM Bldg. #643, Massachusetts, Boston, MA, 02115, USA

    Antonio C. Bianco, Ana Luiza Maia, Wagner Seixas da Silva & Marcelo A. Christoffolete

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  1. Antonio C. Bianco
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  2. Ana Luiza Maia
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  3. Wagner Seixas da Silva
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  4. Marcelo A. Christoffolete
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Correspondence to Antonio C. Bianco.

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Bianco, A.C., Maia, A.L., da Silva, W.S. et al. Adaptive Activation of Thyroid Hormone and Energy Expenditure. Biosci Rep 25, 191–208 (2005). https://doi.org/10.1007/s10540-005-2885-6

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