Skip to main content
Log in

Adventures and Excursions in Bioassay: The Stepping Stones to Prostacylin

  • Nobel Lecture
  • Published:
Bioscience Reports

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Feldberg, W. (1967) John Henry Gaddum, Biographical Memoirs of Fellows of the Royal Society 13: 57

  2. J. H. Gaddum (1964) Drugs in our Society The Johns Hopkins Press Baltimore, MD 17–26

    Google Scholar 

  3. U. S. Euler Particlevon (1936) Biochim. Biophys. Acta 499 48

    Google Scholar 

  4. S. H. Ferreira J. R. Vane (1967) Nature (Lond.) 216 868

    Google Scholar 

  5. A. L. Willis (1969) J. Pharm. Pharmacol 21 126 Occurrence Handle4388094

    PubMed  Google Scholar 

  6. A. L. Willis (1969) Prostaglandins, Peptides and Amines Academic Press New York 31–38

    Google Scholar 

  7. K. Herbaczynska-Cedro J.R. Vane (1973) Circ. Res 33 428 Occurrence Handle4355037

    PubMed  Google Scholar 

  8. A. J. Lonigro H.D. Itskovitz K. Crowshaw J.C. McGiff (1973) Circ. Res 32 712 Occurrence Handle4715193

    PubMed  Google Scholar 

  9. A. J. Lonigro N. A. Terragno K. U. Malik JC McGiff (1973) Prostaglandins 3 595 Occurrence Handle10.1016/0090-6980(73)90097-X Occurrence Handle4354091

    Article  PubMed  Google Scholar 

  10. J. R. Vane (1971) Nature (New Biol.) 231 IssueID25 232

    Google Scholar 

  11. J. B. Smith A. L. Willis (1971) Nature (New Biol.) 231 235

    Google Scholar 

  12. S. H. Ferreira S. Moncada J. R. Vane (1971) Nature (New Biol.) 231 IssueID25 237

    Google Scholar 

  13. W. Feldberg K. P. Gupta A. S. Milton S. Wendlandt (1973) J. Physiol. (Lond.) 234 279

    Google Scholar 

  14. P. J. Piper J. R. Vane (1969) Nature (Lond.) 223 29

    Google Scholar 

  15. M Hamberg J. Svensson B. Samuelsson (1975) Proc. Natl. Acad. Sci. U.S.A 72 2994 Occurrence Handle1059088

    PubMed  Google Scholar 

  16. S Moncada R. J. Gryglewski S. Bunting J. R. Vane (1976) Nature (Lond.) 263 663 Occurrence Handle10.1038/263663a0

    Article  Google Scholar 

  17. R. J. Gryglewski S. Bunting S. Moncada R. J. Flower J. R. Vane (1976) Prostaglandins 12 685 Occurrence Handle10.1016/0090-6980(76)90047-2 Occurrence Handle824685

    Article  PubMed  Google Scholar 

  18. S. Moncada R. J. Gryglewski S. Bunting J.R. Vane (1976) Prostaglandins 12 715 Occurrence Handle10.1016/0090-6980(76)90048-4 Occurrence Handle824686

    Article  PubMed  Google Scholar 

  19. R. A. Johnson D. R. Morton J. H. Kinner R. R. Gorman J. R. McGuire F. F. Sun N. Whittaker S. Bunting J. Salmon S. Moncada J. R. Vane (1976) Prostaglandins 12 915 Occurrence Handle10.1016/0090-6980(76)90126-X Occurrence Handle12538

    Article  PubMed  Google Scholar 

  20. J. H. Gaddum (1959) Pharmacol. Rev 11 241 Occurrence Handle13667400

    PubMed  Google Scholar 

  21. R. Magnus (1903) Ergeb. Physiol 2 637 Occurrence Handle10.1007/BF01924075

    Article  Google Scholar 

  22. H. H. Dale (1912) J. Pharmacol. Exp. Ther 4 167

    Google Scholar 

  23. J. H. Gaddum (1953) Brit. J. Pharmacol. Chemother 8 321

    Google Scholar 

  24. B. Finkleman (1930) J. Physiol. (Lond.) 70 145

    Google Scholar 

  25. J. R. Vane (1964) Brit. J. Pharmacol 23 360

    Google Scholar 

  26. M. A. Palmer P. J. Piper J. R. Vane (1973) Brit. J. Pharmacol 49 226

    Google Scholar 

  27. J. G. Collier (1972) Brit. J. Pharmacol 44 383

    Google Scholar 

  28. S. H. Ferreira FS Souza Costa (1976) Eur. J. Pharmacol 39 379 Occurrence Handle10.1016/0014-2999(76)90147-3 Occurrence Handle976327

    Article  PubMed  Google Scholar 

  29. R. J. Gryglewski R. Korburt A. C. Ocetkiewicz (1978) Nature (Lond.) 273 765 Occurrence Handle10.1038/273765a0

    Article  Google Scholar 

  30. S. Bunting S. Moncada J. R. Vane (1976) Brit. J. Pharmacol 57 462P

    Google Scholar 

  31. P. Needleman S. D. Bronson A. Wyche M. Sivakoff K. C. Nicolaou (1978) J. Clin. Invest 61 839 Occurrence Handle346605

    PubMed  Google Scholar 

  32. R. L. Hodge R. D. Lowe J. R. Vane (1966) J. Physiol. (Lond.) 185 613

    Google Scholar 

  33. J. R. Vane (1969) Brit. J. Pharmacol 35 209

    Google Scholar 

  34. S. Moncada S. H. Ferreira J. R. Vane (1978) Advances in Prostaglandin and Thromboxane Research NumberInSeriesVol. 5 Raven Press New York 211–236

    Google Scholar 

  35. P. J. Piper H. O. Collier J. R. Vane (1967) Nature (Lond.) 213 838

    Google Scholar 

  36. J. Staszewska-Barczak J. R. Vane (1965) J. Physiol. (Lond.) 177 57P

    Google Scholar 

  37. J. Stazewska-Barczak J. R. Vane (1965) Brit. J. Pharmac. Chemother 25 728

    Google Scholar 

  38. J. Staszewska-Barczak J. R. Vane (1967) Brit. J. Pharmac. Chemother 30 655

    Google Scholar 

  39. D. Regoli (1966) J. Physiol 183 513 Occurrence Handle4288294

    PubMed  Google Scholar 

  40. S. H. Ferreira J. R. Vane (1967) Brit. J. Pharmac. Chemother 29 367

    Google Scholar 

  41. H. E. Berry J. G. Collier J. R. Vane (1970) Clin. Sci 39 349 Occurrence Handle5459163

    PubMed  Google Scholar 

  42. Y. S. Bakhle J. R. Vane (1974) Physiol. Rev 54 1007 Occurrence Handle4371230

    PubMed  Google Scholar 

  43. R. L. Hodge K. K. G. Ng J. R. Vane (1967) Nature (Lond.) 215 138

    Google Scholar 

  44. J. R. Vane (1966) Pharmac. Rev 18 317

    Google Scholar 

  45. R. W. Ginn J. R. Vane (1968) Nature 219 740 Occurrence Handle5667070

    PubMed  Google Scholar 

  46. S. H. Ferreira Vane (1967) Brit. J. Pharmac. Chemother 30 417

    Google Scholar 

  47. P. J. Piper J. R. Vane J. H. Wyllie (1970) Nature 225 600 Occurrence Handle10.1038/225600a0 Occurrence Handle4983971

    Article  PubMed  Google Scholar 

  48. J. C. McGiff N. A. Terragno J. C. Strand J. B. Lee A. J. Lonigro K. K. F. Ng (1969) Nature 223 742

    Google Scholar 

  49. G. J. Dusting S. Moncada J. R. Vane (1978) Brit. J. Pharmacol 64 315

    Google Scholar 

  50. J. C. McGuire F. F. Sun (1978) Arch. Biochem. Biophys 189 92 Occurrence Handle10.1016/0003-9861(78)90118-2 Occurrence Handle101144

    Article  PubMed  Google Scholar 

  51. R. Gryglewski J. R. Vane (1970) Brit. J. Pharmacol 39 573

    Google Scholar 

  52. K. K. F. Ng J. R. Vane (1967) Nature (Lond.) 216 762

    Google Scholar 

  53. K. K. F. Ng J. R. Vane (1968) Naunyn-Schmiedeberg’s Arch. Pharmak. Exp. Path 259 2

    Google Scholar 

  54. K. K. F. Ng J. R. Vane (1968) Nature (Lond.) 218 144

    Google Scholar 

  55. P. J. Piper J. R Vane (1969) Prostaglandins, Peptides and Amines Academic Press London and New York 15–19

    Google Scholar 

  56. P. Piper J. Vane (1971) Ann. N.Y. Acad. Sci 180 363 Occurrence Handle4106477

    PubMed  Google Scholar 

  57. H. E. Lindsey J. H. Wyllie (1970) Brit. J. Surg 57 738 Occurrence Handle5476751

    PubMed  Google Scholar 

  58. B. N. Davis E. W. Horton P. G. Withrington (1968) Brit. J. Pharmacol 32 127

    Google Scholar 

  59. N. Gilmore J. R. Vane J. H. Wyllie (1969) Prostaglandins, Peptides and Amines Academic Press London and New York 21–29

    Google Scholar 

  60. Liljestrand, G. (1967) ‘Nobel Symposium 2, Prostaglandins’, Stockholm, pp. 107--108

  61. E. Anggard B. Samuelsson (1964) J. Biol. Chem 239 4097 Occurrence Handle14247654

    PubMed  Google Scholar 

  62. R. J. Flower G. Blackwell M. DiRosa L Parente (1981) Mechanisms of Steroid Hormone Action Macmillan Press London 97–114

    Google Scholar 

  63. J. R. Vane R. J. Flower J. A Salmon (1982) Prostaglandins and Related Lipids NumberInSeriesvol. 2, Alan R. Liss Inc New York 21–45

    Google Scholar 

  64. J. Svensson M. Hamberg B. Samuelsson (1975) Acta Physiol. Scand 94 222 Occurrence Handle1155178

    PubMed  Google Scholar 

  65. S. Moncada J. R Vane (1977) Biochemical Aspects of Prostaglandins and Thromboxanes Academic Press New York 155–177

    Google Scholar 

  66. P Needleman S Moncada S Bunting JR Vane M Hamberg B Samuelsson (1976) Nature 261 558 Occurrence Handle10.1038/261558a0 Occurrence Handle934294

    Article  PubMed  Google Scholar 

  67. S. Moncada P. Needleman S. Bunting J. R. Vane (1976) Prostaglandins 12 323 Occurrence Handle10.1016/0090-6980(76)90014-9 Occurrence Handle968048

    Article  PubMed  Google Scholar 

  68. Moncada, S. and Vane, J. R. (1977) Harvard Medical School Bicentennial Celebration Proceedings, John Wiley (in press 1983)

  69. N. Whittaker (1977) Tetrahedron Lett 32 2805 Occurrence Handle10.1016/S0040-4039(01)83078-1

    Article  Google Scholar 

  70. S. Moncada A. G. Herman E. A. Higgs J. R. Vane (1977) Thromb. Res 11 323 Occurrence Handle10.1016/0049-3848(77)90185-2 Occurrence Handle335560

    Article  PubMed  Google Scholar 

  71. B. B. Weksler A. J. Marcus E. A. Jaffe (1977) Proc. Natl. Acad. Sci. USA 74 3922 Occurrence Handle333448

    PubMed  Google Scholar 

  72. D. E. MacIntyre J. D. Pearson J. L. Gordon (1978) Nature 271 549 Occurrence Handle10.1038/271549a0 Occurrence Handle340965

    Article  PubMed  Google Scholar 

  73. S. Moncada J. R. Vane (1979) Pharmac. Rev 30 293

    Google Scholar 

  74. B. J. R. Whittle (1980) Gastro-intestinal Mucosal Blood Flow Churchill Livingstone Edinburgh, London 180–191

    Google Scholar 

  75. L. Axelrod L. Levine (1981) Diabetes 30 163 Occurrence Handle7009268

    PubMed  Google Scholar 

  76. F. B. Ubatuba S. Moncada J. R. Vane (1979) Thromb. Diath. Haemorrh 41 425

    Google Scholar 

  77. A. Szczeklik R. J. Gryglewski R. Nizankowski J. Musial R. Pieton J. Mruk (1978) Pharmac. Res. Commun 10 545

    Google Scholar 

  78. Aiken, J. W., Gorman, R. R., and Shebuski, R. J. (1979) 17: 483

  79. B.-L. Bayer K. E. Blass W. Forster (1979) Brit. J. Pharmacol 66 10

    Google Scholar 

  80. Rosenblum, W. I. and E1 Sabban F Stroke (1979) 10: 399

  81. R. R. Gorman S. Bunting O. V. Miller (1977) Prostaglandins 13 377 Occurrence Handle10.1016/0090-6980(77)90018-1 Occurrence Handle191876

    Article  PubMed  Google Scholar 

  82. J. E. Tateson S. Moncada J. R. Vane (1977) Prostaglandins 13 389 Occurrence Handle10.1016/0090-6980(77)90019-3 Occurrence Handle191877

    Article  PubMed  Google Scholar 

  83. R. Kaser-Glanzmann M. Jakabova J. George E. Luscher (1977) Biochim. Biophys. Acta 466 429 Occurrence Handle192295

    PubMed  Google Scholar 

  84. E. G. Lapetina C. J. Schmitges K. Chandrabose P. Cuatrecasas (1977) Biochem. Biophys. Res. Commun 76 828 Occurrence Handle10.1016/0006-291X(77)91575-3 Occurrence Handle197928

    Article  PubMed  Google Scholar 

  85. M. Minkes M. Stanford M. Chi G. Roth A. Raz P. Needleman P. Majerus (1977) J. Clin. Invest 59 449 Occurrence Handle190267

    PubMed  Google Scholar 

  86. C. Malmsten E. Granstrom B. Samuelsson (1976) Biochem. Biophys. Res. Commun 68 569 Occurrence Handle10.1016/0006-291X(76)91183-9 Occurrence Handle175797

    Article  PubMed  Google Scholar 

  87. S. Moncada (1982) Brit. J. Pharmacol 76 3

    Google Scholar 

  88. G. A. Higgs S. Moncada J. R. Vane (1978) J. Physiol. (Lond.) 280 55P

    Google Scholar 

  89. Higgs, G. A. Cardiovascular Pharmacology of the Prostaglandins, Raven Press, New York, pp. 315–325

  90. L. A. Boxer J. M. Allen M. Schmidt M. Yoder R. L. Baehner (1980) J. Lab. Clin. Med 95 672 Occurrence Handle6245158

    PubMed  Google Scholar 

  91. N. K. Hopkins R. R. Gorman (1981) J. Clin. Invest 67 540 Occurrence Handle6257764

    PubMed  Google Scholar 

  92. A. I. Schafer M. A. Gimbrone SuffixJr. R. I. Handin (1980) Biochem. Biophys. Res. Commun 96 1640 Occurrence Handle10.1016/0006-291X(80)91362-5 Occurrence Handle6255950

    Article  PubMed  Google Scholar 

  93. A. A. F. Brotherton J. C. Hoak (1982) Proc. Natl. Acad. Sci. USA 79 495 Occurrence Handle6281772

    PubMed  Google Scholar 

  94. E. A. Higgs S. Moncada J. R. Vane J. P. Caen H. Michel G. Tobelem (1978) Prostaglandins 16 17 Occurrence Handle10.1016/0090-6980(78)90197-1 Occurrence Handle360299

    Article  PubMed  Google Scholar 

  95. B. J. R. Whittle (1980) Brain Res. Bull 5 IssueIDSuppl. 1 7 Occurrence Handle10.1016/0361-9230(80)90297-X Occurrence Handle6992947

    Article  PubMed  Google Scholar 

  96. J. R. Vane (1983) Advances in Prostaglandin, Thromboxane and Leukotriene Research NumberInSeriesVol. 11 Raven Press New York 449–456

    Google Scholar 

  97. B. F. Jugdutt G. M. Hutchins B. H. Bulkley L. C. Becker (1979) Clin. Res 27 177A

    Google Scholar 

  98. M. L. Ogletree A. M. Lefer J. B. Smith K. C. Nicolaou (1979) Eur. J. Pharmacol 56 95 Occurrence Handle10.1016/0014-2999(79)90438-2 Occurrence Handle467518

    Article  PubMed  Google Scholar 

  99. L. G. T Ribeiro T. A. Brandon D. G. Hopkins L. A. Reduto A. A. Taylor R. R. Miller (1981) Am. J. Cardiol 47 835 Occurrence Handle10.1016/0002-9149(81)90182-X Occurrence Handle7010977

    Article  PubMed  Google Scholar 

  100. V. A. Staines R. K. Primm R. L. Woolsey J. A. Oates J. W. Hammon (1982) J. Cardiovasc. Pharmacol 4 765 Occurrence Handle6182407

    PubMed  Google Scholar 

  101. R. Ohlendorf E. Perzborn K. Schror (1980) Thromb. Res 19 447 Occurrence Handle10.1016/0049-3848(80)90017-1 Occurrence Handle7003802

    Article  PubMed  Google Scholar 

  102. R. H. Demling M. Smith R. Gunther M. Gee J. Flynn (1981) Surgery 89 257 Occurrence Handle7006136

    PubMed  Google Scholar 

  103. J. R. Fletcher P. W. Ramwell (1980) Circ. Shock 7 299 Occurrence Handle7004660

    PubMed  Google Scholar 

  104. A. M. Lefer J. Tabas E. F. Smith SuffixIII (1980) Pharmacology 21 206 Occurrence Handle6997895

    PubMed  Google Scholar 

  105. H. Araki A. M. Lefer (1980) Am. J. Physiol 238 H176 Occurrence Handle6987902

    PubMed  Google Scholar 

  106. M. Monden J. G. Fortner (1982) Ann. Surg 196 38 Occurrence Handle7046655

    PubMed  Google Scholar 

  107. S. Moncada M. Radomski J. R. Vargas (1982) Brit. J. Pharmacol 75 165P

    Google Scholar 

  108. G. J. Blackwell M. Radomski J. R. Vargas S. Moncada (1982) Biochim. Biophys. Acta 718 60 Occurrence Handle6291622

    PubMed  Google Scholar 

  109. K. Schror R. Ohlendorf H. Darius (1981) J. Pharmac. Exp. Ther 219 243

    Google Scholar 

  110. S. Bunting R. Gryglewski S. Moncada J. R. Vane (1976) Prostaglandins 12 897 Occurrence Handle10.1016/0090-6980(76)90125-8 Occurrence Handle1005741

    Article  PubMed  Google Scholar 

  111. J. A. Salmon D. R. Smith R. J. Flower S. Moncada J. R. Vane (1978) Biochim. Biophys. Acta 523 250 Occurrence Handle415760

    PubMed  Google Scholar 

  112. J. Glavind S. Hartmann J. Clemmesen K. E. Jessen H. Dam (1952) Acta Pathol. Microbiol. Scand 30 1 Occurrence Handle14933036

    PubMed  Google Scholar 

  113. T. F. Slater (1972) Free Radical Mechanisms in Tissue Injury Pion Ltd London

    Google Scholar 

  114. H. S. Mickel J. Horbar (1974) Lipids 9 68 Occurrence Handle4205771

    PubMed  Google Scholar 

  115. V. D’Angelo S. Villa M. Mysliwiec M. B. Donati G. Gaetano ParticleDe (1978) Thromb. Diath. Haemorrh 39 535

    Google Scholar 

  116. H. Sinzinger W. Feigl K. Silberbauer (1979) Lancet ii 469

    Google Scholar 

  117. A. Eldor D. J. Facone D. P. Hajjar C. R. Minick B. B. Weksler (1982) Am. J. Pathol 107 186 Occurrence Handle7044131

    PubMed  Google Scholar 

  118. A. M. Boyd J. Marks (1963) Angiology 14 198 Occurrence Handle14014673

    PubMed  Google Scholar 

  119. K. Haeger (1968) Vasc. Dis 5 199 Occurrence Handle4177853

    PubMed  Google Scholar 

  120. J. Marks (1962) Vitamins. and Hormones 20 573

    Google Scholar 

  121. J. R. Vane (1982) J. Endocrinol 95 3P Occurrence Handle6816886

    PubMed  Google Scholar 

  122. R. C. Peatfield M. J. Gawel F. Clifford Rose (1981) Headache 21 190 Occurrence Handle10.1111/j.1526-4610.1981.hed2105190.x Occurrence Handle7026501

    Article  PubMed  Google Scholar 

  123. A. E. S Gimson R. D. Hughes P. J. Mellon H. F. Woods P. G. Langley J. Canalese R. Williams M. J. Weston (1980) Lancet i 173 Occurrence Handle10.1016/S0140-6736(80)90661-3

    Article  Google Scholar 

  124. A. E. S. Gimson S. Braude P. J. Mellon J. Canalese R. Williams (1982) Lancent ii 681

    Google Scholar 

  125. J. G. Bennett D. B. Longmore J O’Grady (1981) Clinical Pharmacology of Prostacyclin Raven Press New York 201–208

    Google Scholar 

  126. S. Bunting J. O’Grady J.-N. Fabiani E. Terrier S. Moncada J. R Vane (1981) Clinical Pharmacology of Prostacyclin Raven Press New York 181–193

    Google Scholar 

  127. J. Chelly A. Tricot A. Garcia J.-C. Boucherie J.-N. Fabiani J. Passelecq Ch Dubost (1981) Clinical Pharmacology of Prostacyclin Raven Press, New York 209

    Google Scholar 

  128. K. Radegran N. Egberg C. Papaconstantinou (1981) Scand. J. Thoracic Cardiovasc. Surg 15 263

    Google Scholar 

  129. I. D. Walker J. F. Davidson A. Faichney D. Wheatley K Davidson (1981) Clinical Pharmacology of Prostacyclin Raven Press New York 195–199

    Google Scholar 

  130. D. B. Longmore J. G. Bennett P. M. Hoyle M. A. Smith A. Gregory T. Osivand W. A. Jones (1981) Lancet i 800

    Google Scholar 

  131. C. R. Nobak J. H. Tinker M. P. Kaye G. R. Holcomb J. R. Pluth (1980) Circulation 62 IssueIDSuppl. 3 1242

    Google Scholar 

  132. Negus D (1981) Hormones and Vascular Disease, Pitman Medical, p. 181

  133. A. G. Olsson (1980) Lancet ii 1076 Occurrence Handle10.1016/S0140-6736(80)92290-4

    Article  Google Scholar 

  134. B. J. H. Pardy J. D. Lewis H. H. G. Eastcott (1980) Surgery 88 826 Occurrence Handle7003784

    PubMed  Google Scholar 

  135. O. Soreide L. Segadahl A. Trippestad H. Engeda (1982) Scand. J. Thoracic Cardiovasc. Surg 16 71

    Google Scholar 

  136. A. Szczeklik R. Nizankowski S. Skawinski J. Szczeklik P. Gluszko R. J. Gryglewski (1979) Lancet i 1111

    Google Scholar 

  137. A. Szczeklik R Gryglewski (1981) Clinical Pharmacology of Prostacyclin Raven Press New York 159–167

    Google Scholar 

  138. J. J. F Belch A. McKay B. McArdle P. Lieberman J. G. Pollock G. D. O Lowe C. D. C. R. M Forbes Prentice (1983) Lancet i 315

    Google Scholar 

  139. H. Zygulska-Mach E. Kostka-Trabka A. Niton R. J. Gryglewski (1980) Lancet ii 1075

    Google Scholar 

  140. P. M. Dowd M. F. R Martin E. D. Cooke S. A. Bowcock R. Jones P. A. Dieppe J. D. T. Kirby (1982) Brit. J. Dermatol 106 81

    Google Scholar 

  141. J. J. F Belch P. Newman J. K. Drury H. Capell P. Leiberman W. B. James C. D. Forbes C. R. M. Prentice (1981) Thromb. Haem 45 255

    Google Scholar 

  142. J. J. F Belch P. Newman J. K. Drury F. McKenzie H. Capell P. Leiberman C. D. Forbes C. R. M. Prentice (1983) Lancet i 313

    Google Scholar 

  143. R. J. Gryglewski S. Nowak E. Kostka-Trabka K. Bieron A. Dembinska-Kiec B. Blaszczyk J. Kusmiderski E. Markowska S. Szmatola (1982) Pharm. Res. Commun 14 879

    Google Scholar 

  144. W. D. Watkins M. B. Peterson R. K. Crone D. C. Shannon L. Levine (1980) Lancet i 1083

    Google Scholar 

  145. Rubin, L. J., Groves, B. M., Reeves, J. T., Frosolono, M., Handel, F., and Cato, A. E. (1982) Circulation 66(2)Part 1: 334

    Google Scholar 

  146. J. Szczeklik A. Szczeklik R. Nizankowski (1980) Lancet ii 1076 Occurrence Handle10.1016/S0140-6736(80)92290-4

    Article  Google Scholar 

  147. J. E. Lock P. M. Olley F. Coceani P. R. Swyer R. D. Rowe (1979) Lancet i 1343 Occurrence Handle10.1016/S0140-6736(79)91970-6

    Article  Google Scholar 

  148. J. Fidler M. J. Bennett M. Swiet Particlede C. Ellis P. J. Lewis (1980) Lancet ii 31 Occurrence Handle10.1016/S0140-6736(80)92904-9

    Article  Google Scholar 

  149. Y. Yui H. Nakajima C. Kawai T. Murakami (1982) Am. J. Cardiol 50 320 Occurrence Handle10.1016/0002-9149(82)90183-7 Occurrence Handle7048886

    Article  PubMed  Google Scholar 

  150. G. Bergman R. Daly L. Atkinson M. Rothman P. J. Richardson G. Jackson D. E. Jewitt (1981) Lancet i 569 Occurrence Handle10.1016/S0140-6736(81)92028-6

    Article  Google Scholar 

  151. R. J. C. Hall H. A. Dewar (1981) Lancet i 949 Occurrence Handle10.1016/S0140-6736(81)91648-2

    Article  Google Scholar 

  152. S. Chierchia C. Patrono F. Crea G. Ciabattoni R. de Caterina G. A. Cinotti A. Distante A. Maseri (1982) Circulation 65 470 Occurrence Handle7034990

    PubMed  Google Scholar 

  153. C. N. Hensby P. J. Lewis P. Hilgard G. J. Mufti J. Hows J. Webster (1979) Lancet ii 748 Occurrence Handle10.1016/S0140-6736(79)90680-9

    Article  Google Scholar 

  154. G. T. Budd R. M. Bukowski F. V. Lucas A. E. Cato D. M. Cocchetto (1980) Lancet ii 915

    Google Scholar 

  155. G. A. FitzGerald L. J. Roberts SuffixII D. Maas A. R. Brash J. A Oates (1981) Clinical Pharmacology of Prostacyclin Raven Press New York p. 81

    Google Scholar 

  156. A. R. Mundy M. Bewick S. Moncada J. R. Vane (1980) Prostaglandins 19 595 Occurrence Handle6992233

    PubMed  Google Scholar 

  157. C. Leithner H. Sinzinger M. Schwarz (1981) Prostaglandins 22 783 Occurrence Handle10.1016/0090-6980(81)90217-3 Occurrence Handle7036226

    Article  PubMed  Google Scholar 

  158. J. Fidler C. Ellis M. J. Bennett M. Swiet Particlede P. J Lewis (1981) Clinical Pharmacology of Prostacyclin Raven Press New York 141–143

    Google Scholar 

  159. J. Webster L. K. Borysiewicz A. J. Rees P. J Lewis (1981) Clinical Pharmacology of Prostacyclin Raven Press, New York pp. 77–80

    Google Scholar 

  160. B. J. R. Whittle G. L. Kauffman S. Moncada (1981) Nature 292 472 Occurrence Handle10.1038/292472a0 Occurrence Handle7195986

    Article  PubMed  Google Scholar 

  161. K. V. Honn B. Cicone A. Skoff (1981) Science 212 1270 Occurrence Handle7015512

    PubMed  Google Scholar 

  162. T. Utsunomiya M. M. Krausz C. R. Valeri D. Shepro H. B. Hechtman (1980) Surgery 88 25 Occurrence Handle6992319

    PubMed  Google Scholar 

  163. 163. Vane, J. R. (1971) Identification of Asthma. Churchill Livingstone, pp. 121–131.

  164. S. Moncada E. A. Higgs J. R. Vane (1977) Lancet i 18 Occurrence Handle10.1016/S0140-6736(77)91655-5

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vane, J.R. Adventures and Excursions in Bioassay: The Stepping Stones to Prostacylin. Biosci Rep 24, 254–279 (2004). https://doi.org/10.1007/s10540-005-2734-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10540-005-2734-7

Navigation