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Biology & Philosophy

, 33:2 | Cite as

The generality of Constructive Neutral Evolution

  • T. D. P. Brunet
  • W. Ford Doolittle
Article
  • 357 Downloads

Abstract

Constructive Neutral Evolution (CNE) is an evolutionary mechanism that can explain much molecular inter-dependence and organismal complexity without assuming positive selection favoring such dependency or complexity, either directly or as a byproduct of adaptation. It differs from but complements other non-selective explanations for complexity, such as genetic drift and the Zero Force Evolutionary Law, by being ratchet-like in character. With CNE, purifying selection maintains dependencies or complexities that were neutrally evolved. Preliminary treatments use it to explain specific genetic and molecular structures or processes, such as retained gene duplications, the spliceosome, and RNA editing. Here we aim to expand the scope of such explanation beyond the molecular level, integrating CNE with Multi-Level Selection theory, and arguing that several popular higher-level selection scenarios are in fact instances of CNE. Suitably contextualized, CNE occurs at any level in the biological hierarchy at which natural selection as normally construed occurs. As examples, we focus on modularity in protein–protein interaction networks or “interactomes,” the origin of eukaryotic cells and the evolution of co-dependence in microbial communities—a variant of the “Black Queen Hypothesis” which we call the “Gray Queen Hypothesis”.

Keywords

Constructive Neutral Evolution Evolution of complexity Black Queen Hypothesis Eukaryogenesis Protein–protein interaction networks Interactome 

Abbreviations

CNE

Constructive Neutral Evolution

PPI

Protein–protein interaction networks

ZFEL

Zero-force evolutionary law

BQH

Black Queen Hypothesis

GQH

Gray Queen Hypothesis

Notes

Acknowledgements

We thank Dr. S. A. Inkpen, and the Dalhousie-Kings STS reading group for helpful comments, and NSERC Discovery Grant GLDSU 447989 for support.

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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of History and Philosophy of ScienceUniversity of CambridgeCambridgeUK
  2. 2.Department of Biochemistry and Molecular BiologyDalhousie UniversityHalifaxCanada

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