In defense of the organism
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Thomas Pradeu’s The Limits of the Self provides a precise account of biological identity developed from the central concepts of immunology. Yet the central concepts most relevant to this task (self and nonself) are themselves deemed inadequate, suffering from ambiguity and imprecision. Pradeu seeks to remedy this by proposing a new guiding theory for immunology, the continuity theory. From this, an account of biological identity is provided in terms of uniqueness and individuality, ultimately leading to a defense of the heterogeneous organism as expressing the highest degree of individuality.
KeywordsImmunology Organism Development Physiology Identity Self-nonself
Thanks to Fred Adler, Stephen Downes, Melinda Fagan, Daniel Gustafsson, Lucas Matthews, Dan Molter, James Moore, Melanie Murphy, Steven Peck, Thomas Pradeu, Jonah Schupbach, Jim Tabery, Blake Vernon, and Chris Zarpentine for their engaged and enlightening discussion of this book.
- Godfrey-Smith P (2009) Darwinian populations and natural selection. Oxford University Press, New YorkGoogle Scholar
- Haber MH (2013) Colonies are individuals: revisiting the superorganism revival. In: Bouchard F, Huneman P (eds) From groups to individuals: evolution and emerging individuality. MIT Press, Cambridge, pp 195–217Google Scholar
- Hodge JW, Garnett CT, Farsaci B, Palena C, Tsang KY, Ferrone S, Gameiro SR (2013) Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death. Int J Cancer 133(3):624–636. doi: 10.1002/ijc.28070 CrossRefGoogle Scholar
- Mishler BD (1999) Getting rid of species. In: Wilson RA (ed) Species: new interdisciplinary essays. MIT Press, Cambridge, pp 141–185Google Scholar
- Pradeu T (2012) The limits of the self: immunology and biological identity. Oxford University Press, New YorkGoogle Scholar
- Turnbaugh PJ, Quince C, Faith JJ, McHardy AC, Yatsunenko T, Niazi F, Affourtit J, Egholm M, Henrissat B, Knight R, Gordon JI (2010) Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins. Proc Natl Acad Sci 107(16):7503–7508. doi: 10.1073/pnas.1002355107 CrossRefGoogle Scholar