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Biology & Philosophy

, Volume 27, Issue 2, pp 241–261 | Cite as

Evolutionary medicine at twenty: rethinking adaptationism and disease

Article

Abstract

Two decades ago, the eminent evolutionary biologist George C. Williams and his physician coauthor, Randolph Nesse, formulated the evolutionary medicine research program. Williams and Nesse explicitly made adaptationism a core component of the new program, which has served to undermine the program ever since, distorting its practitioners’ perceptions of evidentiary burdens and in extreme cases has served to warp practitioner’s understandings of the relationship between evolutionary benefits/detriments and medical ones. I show that the Williams and Nesse program more particularly embraces the panselectionist variety of adaptationism (the empirical assumption that non-adaptive evolutionary processes are causally unimportant compared to natural selection), and argue that this has harmed the field. Panselectionism serves to conceal the enormous evidentiary hurdles that evolutionary medicine hypotheses face, making them appear stronger than they are. I use two examples of evolutionary medicine texts, on neonatal jaundice and on asthma, to show that some evolutionary medicine practitioners have allowed their fervent panselectionism to directly shape their recommendations for clinical practice. I argue that this escalation of panselectionism’s influence is inappropriate under Williams’ and Nesse original stated standards, despite being inspired by their program. I also show that the examples’ conflation of clinical and evolutionary considerations is inappropriate even under Christopher Boorse’s controversial evolution-rooted concepts of disease and health.

Keywords

Adaptationism Biostatistical theory Darwinian medicine Evolutionary medicine Maladaptation Panselectionism 

Notes

Acknowledgments

I would like to thank Lisa Lloyd and Steve Lawrie for their patient and illuminating comments on the paper. I would also like to thank Marilyn Valles, R.N. for providing valuable background information on neonatal clinical care. Finally, I am indebted to the anonymous reviewer for his or her helpful comments and suggestions. All errors, of course, are mine alone.

References

  1. Anderson R (1999) Human evolution, low back pain, and dual-level control. In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine. Oxford University Press, New YorkGoogle Scholar
  2. Barnes KC, Armelagos GJ, Morreale SC (1999) Darwinian medicine and the emergence of allergy. In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine. Oxford University Press, New YorkGoogle Scholar
  3. Bergstrom CT, Lo M, Lipsitch M (2004) Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals. Proc Nat Acad Sci 101(36):13285–13290CrossRefGoogle Scholar
  4. Bolton D (2008) What is mental disorder? An essay in philosophy, Science and Values. Oxford University Press, New YorkGoogle Scholar
  5. Boorse C (1975) On the distinction between disease and illness. Philos Public Aff 5(1):49–68Google Scholar
  6. Boorse C (2010) A rebuttal on health. In: Humber JM, Almeder RF (eds) What Is disease?. Humana Press, TotowaGoogle Scholar
  7. Brett J, Niermeyer S (1999) Is neonatal jaundice a disease or an adaptive process? In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine. Oxford University Press, New YorkGoogle Scholar
  8. Cahill DP, Kinzler KW, Vogelstein B, Lengauer C (1999) Genetic instability and Darwinian selection in tumours. Trends Cell Biol 9(12):M57–M60CrossRefGoogle Scholar
  9. Chisholm JS, Coall DA (2008) Not by bread alone: the role of psychosocial stress in age at first reproduction and health inequalities. In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine and health. Oxford University Press, New York, pp 134–148Google Scholar
  10. DeVito S (2000) On the value-neutrality of the concepts of health and disease: unto the breach again. J Med Philos 25(5):539–567CrossRefGoogle Scholar
  11. Gluckman P, Beedle A, Hanson M (2009) Principles of evolutionary medicine. Oxford University Press, New YorkGoogle Scholar
  12. Gould SJ, Lewontin RC (1979) The spandrels of san marco and the Panglossian paradigm: a critique of the adaptationist programme proceedings of the royal society of london series B. Biol Sci 205(1161):581–598CrossRefGoogle Scholar
  13. Gourley GR (2000) Breastfeeding, diet, and neonatal hyperbilirubinemia. Neoreviews 1(2):e25–e31CrossRefGoogle Scholar
  14. Hendry AP, Gonzalez A (2008) Whither adaptation? Biol Philos 23(5):673–699CrossRefGoogle Scholar
  15. Horwitz AV, Wakefield JC (2007) The loss of sadness: how psychiatry transformed normal sorrow into depressive disorder, Oxford University Press, New YorkGoogle Scholar
  16. Humber JM, Almeder RF (eds) (2010) What is disease?. Humana Press, TotowaGoogle Scholar
  17. Hurtado AM, Hurtado IID, Sapien R, Hill K (1999) The evolutionary ecology of childhood asthma. In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine. Oxford University Press, New YorkGoogle Scholar
  18. Kaplan JM (2002) Historical evidence and human adaptations. Philos Sci 69(S3):S294–S304CrossRefGoogle Scholar
  19. Kingma E (2010) Paracetamol, poison, and polio: why boorse’s account of function fails to distinguish health and disease. Br J Philos Sci 61(2):241–264CrossRefGoogle Scholar
  20. Lewens T (2009) Seven types of adaptationism. Biol Philos 24(2):161–182CrossRefGoogle Scholar
  21. Lewis S (2008) Evolution at the intersection of biology and medicine. In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine and health. Oxford University Press, New YorkGoogle Scholar
  22. Livingstone FB (1969) The founder effect and deleterious genes. Am J Phys Anthropol 30(1):55–59CrossRefGoogle Scholar
  23. Maimburg RD, Bech BH, Væth M, Møller-Madsen B, Olsen J (2010) Neonatal jaundice, autism, and other disorders of psychological development. Pediatrics 126(5):872–878CrossRefGoogle Scholar
  24. Maisels MJ, Baltz RD, Bhutani VK, Newman TB, Palmer H, Rosenfeld W, Stevenson DK, Weinblatt HB (2004) Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114(1):297–316CrossRefGoogle Scholar
  25. Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko JF (2009) Hyperbilirubinemia in the newborn infant ≤35 weeks gestation: an update with clarifications. Pediatrics 124(4):1193–1198CrossRefGoogle Scholar
  26. Martin RD (2007) The evolution of human reproduction: a primatological perspective. Am J Phys Anthropol 134(Supplement 45):59–84CrossRefGoogle Scholar
  27. McDonagh AF (2010) Controversies in bilirubin biochemistry and their clinical relevance. Sem Fetal Neonatal Med 15(3):141–147CrossRefGoogle Scholar
  28. Merlo LMF, Pepper JW, Reid BJ, Maley CC (2006) Cancer as an evolutionary and ecological process. Nat Rev Cancer 6(12):924–935CrossRefGoogle Scholar
  29. Mitchell SD, Dietrich MR (2006) Integration without unification: an argument for pluralism in the biological sciences. Am Nat 168(Supplement):S73–S79CrossRefGoogle Scholar
  30. Nesse RM (2001) On the difficulty of defining disease: a Darwinian perspective. Med Health Care Philos 4(1):37–46CrossRefGoogle Scholar
  31. Nesse RM (2005) Maladaptation and natural selection. Q Rev Biol 80(1):62–70CrossRefGoogle Scholar
  32. Nesse RM (2008) The importance of evolution for medicine. In: Trevathan WR, Smith EO, McKenna JJ (eds) Evolutionary medicine and health. Oxford University Press, New York, pp 416–432Google Scholar
  33. Nesse RM, Stearns SC (2008) The great opportunity: evolutionary applications to medicine and public health. Evol Appl 1(1):28–48CrossRefGoogle Scholar
  34. Nesse RM, Williams GC (1996) Why we get sick: the new science of Darwinian medicine. Vintage Books, New YorkGoogle Scholar
  35. Profet M (1993) Menstruation as a defense against pathogens transported by sperm. Q Rev Biol 68(3):335–386CrossRefGoogle Scholar
  36. Purushotham AD, Sullivan R (2010) Darwin, medicine and cancer. Ann Oncol 21(2):199–203CrossRefGoogle Scholar
  37. Sedlak TW, Snyder SH (2004) Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113(6):1776–1782CrossRefGoogle Scholar
  38. Stearns SC (2000) Clinical adaptationists. Trends Ecol Evol 15(4):175CrossRefGoogle Scholar
  39. Stearns SC, Ebert D (2001) Evolution in health and disease. Q Rev Biol 76(4):417–432CrossRefGoogle Scholar
  40. Tinbergen N (1963) On aims and methods of ethology. Zeitschrift für Tierpsychologie 20(4):410–433CrossRefGoogle Scholar
  41. Trevathan WR, Smith EO, McKenna JJ (eds) (1999) Evolutionary medicine. Oxford University Press, New YorkGoogle Scholar
  42. Valles SA (2010) The mystery of the mystery of common genetic diseases. Biol Philos 25(2):183–201CrossRefGoogle Scholar
  43. Welford M, Bossak BH (2010) Revisiting the medieval black death of 1347–1351: spatiotemporal dynamics suggestive of an alternate causation. Geogr Compass 4(6):561–575CrossRefGoogle Scholar
  44. Williams GC (1966) Adaptation and natural selection: a critique of some current evolutionary thought. Princeton University Press, PrincetonGoogle Scholar
  45. Williams GC, Nesse RM (1991) The dawn of Darwinian medicine. Q Rev Biol 66(1):1–22CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Lyman Briggs College and Department of PhilosophyMichigan State UniversityEast LansingUSA

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