Abstract
In the present work the two new Cu(II) complexes, (µ-acetato)-bis(2,2′-bipyridine)-copper [Cu(bpy)2(CH3CO2)] and bromidotetrakis(2-methyl-1H-imidazole)-copper bromide [Cu(2-methylimid)4Br]Br have been synthesized by liquid assisted mechanochemical method. The [Cu(bpy)2(CH3CO2)] complex (1) and [Cu(2-methylimid)4Br]Br complex (2) characterised by IR and UV–visible spectroscopy and the structure are confirmed by XRD diffraction studies. Complex (1) crystallized in the Monoclinic with the space group of C2/c where a = 24.312(5) Å, b = 8.5892(18) Å, c = 14.559(3) Å, α = 90°, β = 106.177(7)° and γ = 90° and Complex (2) crystallized in the Tetragonal with the space group of P4nc, a = 9.9259(2) Å, b = 9.9259(2) Å, c = 10.9357(2) Å, α = 90°, β = 90° and γ = 90°. The complex (1) has distorted octahedral geometry where the acetate ligand showed bidentate bridging with the central metal ion and complex (2) has slightly deformed square pyramidal geometry. The HOMO–LUMO energy gap value and the low chemical potential showed that the complex (2) is stable and difficult to polarize compare to complex (1). The molecular docking study of complexes with the HIV instasome nucleoprotein showed the binding energy values − 7.1 and − 5.3 kcal/mol for complex (1) and complex (2) respectively. The negative binding energy values showed the complexes have affinity to bind with HIV instasome nucleoproteins. The in-silico pharmacokinetic study of the complex (1) and complex (2) showed non AMES toxicity, non-carcinogens and low honey Bee toxicity but weakly inhibit Human Ether—a-go-go-related gene.
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The authors are thankful to CDRI, Lucknow, U.P. (India) for providing the spectral facilities for UV–visible and IR and SAIF-IIT Madras for XRD facility.
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S.A. Khan made significant contribution in the conception of work, study design, interpretation and critically reviewing of the article. R. Jaryal made the contribution in execution of work, acquisition of data, analysis and manuscript preparation.
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Jaryal, R., Khan, S.A. Liquid-assisted mechanochemical synthesis, crystallographic, theoretical and molecular docking study on HIV instasome of novel copper complexes: (µ-acetato)-bis(2,2′-bipyridine)-copper and bromidotetrakis(2-methyl-1H-imidazole)-copper bromide. Biometals 36, 975–996 (2023). https://doi.org/10.1007/s10534-023-00498-6
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DOI: https://doi.org/10.1007/s10534-023-00498-6