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Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels

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Abstract

This study aimed to investigate the short-term effects of three magnesium (Mg) dietary supplements containing mineral immediately available for absorption on Mg biochemical status indices (ionized and total Mg), as well as their effects on electrolytes levels in healthy female young adults (n = 61). After a 10-days intervention period supplementation with powder/granulate containing Mg oxide led to an increase in both ionized Mg concentration and % in total Mg in comparison with the baseline. Supplementation with Mg citrate was associated with the significant increase in % of ionized fraction and decrease in serum total Mg concentration. By contrast, among participants consuming Mg carbonate in the form of effervescent tablets ionized Mg concentration and % in total Mg decreased, without detectable changes in serum total Mg. In conclusion, after the short-term supplementation period, Mg oxide demonstrated superior bioavailability compared to the other examined Mg supplements without affecting other minerals’ levels.

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Acknowledgements

The authors wish to express their profound appreciation to Nova Biomedical (Waltham, MA, USA) for providing access to Stat Profile Prime Plus Critical Care blood gas analyzer and reagents' donation. Nevertheless, the sponsor had no role in the study design, data collection and analysis, the decision to publish or preparation of the manuscript. We gratefully thank all the students who volunteered to participate in the study for their cooperation, time and motivation. We particularly thank Agnes Kadvan for IT support and technical assistance.

Funding

The authors have no relevant financial or non-financial interests to disclose.

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Authors and Affiliations

  1. Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Serbia

    Nevena Dj Ivanovic & Brizita Djordjevic

  2. Institute of Chemistry in Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Branimir Radosavljevic

  3. Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia

    Milica Zekovic

  4. Faculty of Pharmacy Novi Sad, Business Academy University in Novi Sad, Novi Sad, Serbia

    Davor Korcok

  5. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

    Svetlana Ignjatovic & Neda Milinkovic

  6. Centar for Medical Biochemistry, Clinical Center of Serbia, Beograd, Serbia

    Svetlana Ignjatovic

Authors
  1. Nevena Dj Ivanovic
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  2. Branimir Radosavljevic
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  3. Milica Zekovic
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  4. Davor Korcok
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  5. Svetlana Ignjatovic
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  6. Brizita Djordjevic
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  7. Neda Milinkovic
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Contributions

Conceptualization, NI and NM; methodology, NI, NM, MZ, BR; software, NM; validation, MZ, BDJ, SI, BR; formal analysis, MZ, DK and BDJ; writing—original draft preparation, NI, NM and BR; writing—review and editing, MZ, DK, BDJ and SI; visualization, MZ; supervision, DK; project administration, NI. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Nevena Dj Ivanovic.

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The authors have no conflicts of interest to declare that are relevant to the content of this article.

Ethical approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and its later amendments. Informed consent was obtained from all patients for being included in the study.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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All authors have read and approved the final submitted manuscript. We certify that this manuscript is original and not previously published in any form including on preprint servers, nor is it being considered elsewhere.

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Ivanovic, N.D., Radosavljevic, B., Zekovic, M. et al. Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels. Biometals 35, 267–283 (2022). https://doi.org/10.1007/s10534-022-00363-y

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  • DOI: https://doi.org/10.1007/s10534-022-00363-y

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