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Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis

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Abstract

Desferrioxamine B (DFOB) is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. Although DFOB has a long clinical history for the treatment of chronic iron overload, limitations encourage the development of new analogues. This review describes a recent body of work that has used precursor-directed biosynthesis (PDB) to access new DFOB analogues. PDB exploits the native biosynthetic machinery of a producing organism in culture medium augmented with non-native substrates that compete against native substrates during metabolite assembly. The method allows access to analogues of natural products using benign methods, compared to multistep organic synthesis. The disadvantages of PDB are the production of metabolites in low yield and the need to purify complex mixtures. Streptomyces pilosus medium was supplemented with different types of non-native diamine substrates to compete against native 1,5-diaminopentane to generate DFOB analogues containing alkene bonds, fluorine atoms, ether or thioether functional groups, or a disulfide bond. All analogues retained function as Fe(III) chelators and have properties that could broaden the utility of DFOB. These PDB studies have also added knowledge to the understanding of DFOB biosynthesis.

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Acknowledgements

The Australian Research Council (Grant Nos. DP140100092, DP180100785) is acknowledged for research support. The University of Sydney is acknowledged for providing Australian Postgraduate Awards to TJT, TRS and KPN.

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  1. School of Medical Sciences (Pharmacology), The University of Sydney, Sydney, NSW, 2006, Australia

    Thomas J. Telfer, Tomas Richardson-Sanchez, Michael P. Gotsbacher, Kate P. Nolan, William Tieu & Rachel Codd

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  1. Thomas J. Telfer
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  2. Tomas Richardson-Sanchez
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Telfer, T.J., Richardson-Sanchez, T., Gotsbacher, M.P. et al. Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis. Biometals 32, 395–408 (2019). https://doi.org/10.1007/s10534-019-00175-7

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