Abstract
Global methylation pattern regulates the normal functioning of a cell. Research have shown arsenic alter these methylation landscapes within the genome leading to aberrant gene expression and inducts various pathophysiological outcomes. Long interspersed nuclear elements (LINE-1) normally remains inert due to heavy methylation of it’s promoters, time and various environmental insults, they lose these methylation signatures and begin retro-transposition that has been associated with genomic instability and cancerous outcomes. Of the various high throughput technologies available to detect global methylation profile, development of LINE-1 methylation index shall provide a cost effect-screening tool to detect epimutagenic events in the wake of toxic exposure in a large number of individuals. In the present review, we tried to discuss the state of research and whether LINE-1 methylation can be considered as a potent epigenetic signature for arsenic toxicity.
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Acknowledgements
The authors thank Indian Council of Medical Research (ICMR, India) to provide SRF to SP; University Grants Commission (UGC, India) to provide JRF to P.B and Department of Science and Technology (DST-SERB, India, Grant #2620/2013) to provide grant to Dr. P.B. The authors are also thankful to Council of Scientific and Industrial Research (CSIR), New Delhi, India for providing Emeritus Project Grant #. 21(0885)/12/EMR-II to AKG.
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SP, PB conducted literature survey. SP made the illustrations. AKG and Dr.PB helped in formulation of the table. All the authors contributed in scripting the manuscript.
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Paul, S., Bhattacharjee, P., Giri, A.K. et al. Arsenic toxicity and epimutagenecity: the new LINEage. Biometals 30, 505–515 (2017). https://doi.org/10.1007/s10534-017-0021-2
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DOI: https://doi.org/10.1007/s10534-017-0021-2