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Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution

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Abstract

Vibrio anguillarum is a marine pathogen that causes vibriosis, a hemorrhagic septicemia in aquatic invertebrate as well as vertebrate animals. The siderophore anguibactin system is one of the most important virulence factors of this bacterium. Most of the anguibactin biosynthesis and transport genes are located in the 65-kb pJM1 virulence plasmid although some of them are found in the chromosome of this fish pathogen. Over 30 years of research unveiled the role numerous chromosomal and pJM1 genes play in the synthesis of anguibactin and the transport of cognate ferric complexes into the bacterial cell. Furthermore, these studies showed that pJM1-carrying strains might be originated from pJM1-less strains producing the chromosome-mediated siderophore vanchrobactin. Additionally, we recently identified a chromosome-mediated anguibactin system in V. harveyi suggesting the possible evolutional origin of the V. anguillarum anguibactin system. In this review, we present our current understanding of the mechanisms and evolution hypothesis of the anguibactin system that might have occurred in these pathogenic vibrios.

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Acknowledgments

The authors thank Dr. Lidia M. Crosa for reviewing the manuscript. The author’s work was supported by the National Institutes of Health Grants AI19018 and GM64600 to J. H. C. and AI070174 to L. A. A.

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  1. Hiroaki Naka

    Present address: Division of Environmental and Biomolecular Systems, Oregon Health & Science University, Beaverton, OR, 97006, USA

  2. Moqing Liu

    Present address: Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA

Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA

    Hiroaki Naka, Moqing Liu & Jorge H. Crosa

  2. Department of Microbiology, Miami University, Oxford, OH, USA

    Luis A. Actis

  3. Division of Environmental and Biomolecular Systems, Oregon Health & Science University, 20000 NW Walker Road, Beaverton, OR, 97006, USA

    Hiroaki Naka

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  1. Hiroaki Naka
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Correspondence to Hiroaki Naka.

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Jorge H. Crosa passed away on May 19, 2012.

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Naka, H., Liu, M., Actis, L.A. et al. Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution. Biometals 26, 537–547 (2013). https://doi.org/10.1007/s10534-013-9629-z

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