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Coordinating properties of uridine 5′-monophosphate with selected Ln3+ ions in ionic micellar media

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Abstract

Coordinating properties of uridine 5′-monophosphate (UMP) towards trivalent La, Pr, Nd, Sm, Eu and Gd ions in presence of cationic and anionic micelles have been investigated by potentiometric pH-titration and spectroscopic methods. Stability constants of the 2:1 complexes have been determined and the change in free energy, enthalpy and entropy associated with the complexation are also calculated. Nd(III) complexes isolated from aqueous and aqueous-micellar media do not show any significant structural difference. Formation of Ln(III) complexes in all cases completes below pH 7.5 showing that UMP best interacts with Ln3+ ions at the physiological pH range 7.3–7.5. The nucleobase is not involved in the complexation and the metal ion coordination of UMP is through the phosphate moiety only. Coordinating tendency of UMP with lanthanides, Nd(III) ion in particular, at different pH is also discussed. Luminescent properties of Eu(III) complex and its decay lifetime are also presented. This information may prove helpful regarding the use of lanthanides as biological probes for calcium/magnesium ions.

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Acknowledgments

This research was financed by Department of Science & Technology, New Delhi under Scheme No. SR/SI/PC-39/2003 dated 19/03/2004.

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  1. Department of Chemistry, Manipur University, Canchipur, Imphal, 795 003, Manipur, India

    M. Sudhiranjan Singh, Naorem Homendra & R. K. Lonibala

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  1. M. Sudhiranjan Singh
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  2. Naorem Homendra
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  3. R. K. Lonibala
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Correspondence to R. K. Lonibala.

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Sudhiranjan Singh, M., Homendra, N. & Lonibala, R.K. Coordinating properties of uridine 5′-monophosphate with selected Ln3+ ions in ionic micellar media. Biometals 25, 1235–1246 (2012). https://doi.org/10.1007/s10534-012-9585-z

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  • DOI: https://doi.org/10.1007/s10534-012-9585-z

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