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Effects of aluminum exposure on the allergic responses and humoral immune function in rats

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An Erratum to this article was published on 21 June 2011

Abstract

This study was conducted to assess effects of aluminum (Al) exposure on allergic responsive reactions and humoral immune function in rats. Forty male Wistar rats (5 weeks old) weighed 110–120 g were randomly allocated into four groups and were orally exposed to 0, 64.18, 128.36, and 256.72 mg/kg body weight aluminum trichloride in drinking water for 120 days. The levels of immunoglobulin (Ig) G, IgA, IgM, IgE, Complement factor (C)3, and C4 in serum were determined by ELISA and nephelometric assays at the end of experiment. The results showed that the levels of IgM, C3, and C4 were lowered, and the levels of IgG, IgA, and IgE were increased in an Al-dose dependent manner. The increased in IgE level and the decreased in C3 and C4 levels indicate that Al induces allergic responses in rats; while the increased levels in IgG and IgA and the decreased level in IgM suggest that Al disorders the humoral immune function in rats.

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Acknowledgments

This study was supported by a grant from the Natural Science Fund of Heilongjiang Province of China C200935)

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Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China

    Yanzhu Zhu, Hao Sun, Chongwei Hu, Hansong Zhao, Bing Shao, Alphajoh A. Bah & Yanfei Li

  2. College of Animal Sciences and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, China

    Jinfeng Xu

Authors
  1. Yanzhu Zhu
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  2. Jinfeng Xu
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  3. Hao Sun
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  4. Chongwei Hu
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  5. Hansong Zhao
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  6. Bing Shao
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  7. Alphajoh A. Bah
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  8. Yanfei Li
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Correspondence to Yanfei Li.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10534-011-9468-8

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Zhu, Y., Xu, J., Sun, H. et al. Effects of aluminum exposure on the allergic responses and humoral immune function in rats. Biometals 24, 973–977 (2011). https://doi.org/10.1007/s10534-011-9443-4

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  • DOI: https://doi.org/10.1007/s10534-011-9443-4

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