BioMetals

, Volume 23, Issue 3, pp 399–409 | Cite as

Cancer prevention by bovine lactoferrin: from animal studies to human trial

  • Hiroyuki Tsuda
  • Takahiro Kozu
  • Gen Iinuma
  • Yasuo Ohashi
  • Yutaka Saito
  • Daizo Saito
  • Takayuki Akasu
  • David B. Alexander
  • Mitsuru Futakuchi
  • Katsumi Fukamachi
  • Jiegou Xu
  • Tadao Kakizoe
  • Masaaki Iigo
Article

Abstract

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and, despite improved colonoscopic screening, CRC is a leading cause of death from cancer. Administration of bovine lactoferrin (bLF) suppresses carcinogenesis in the colon and other organs of test animals, and recently it was shown that ingestion of bLF inhibits the growth of adenomatous polyps in human patients. Here we review work which established bLF as an anti-carcinogenic agent in laboratory animals and the results of a clinical trial which demonstrated that bLF can reduce the risk of colon carcinogenesis in humans.

Keywords

Bovine lactoferrin Chemoprevention Colorectal cancer 

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Hiroyuki Tsuda
    • 1
    • 7
  • Takahiro Kozu
    • 2
  • Gen Iinuma
    • 3
  • Yasuo Ohashi
    • 4
  • Yutaka Saito
    • 5
  • Daizo Saito
    • 5
  • Takayuki Akasu
    • 6
  • David B. Alexander
    • 1
    • 7
  • Mitsuru Futakuchi
    • 7
  • Katsumi Fukamachi
    • 7
  • Jiegou Xu
    • 7
  • Tadao Kakizoe
    • 8
  • Masaaki Iigo
    • 1
    • 7
  1. 1.Nanotoxicology ProjectGraduate School of Medical Sciences, Nagoya City UniversityNagoyaJapan
  2. 2.Cancer Screening DivisionNational Cancer Center, Research Center for Cancer Prevention and ScreeningTokyoJapan
  3. 3.Diagnostic Radiology DivisionNational Cancer Center HospitalTokyoJapan
  4. 4.Department of Biostatistics, School of Health Sciences and NursingThe University of TokyoTokyoJapan
  5. 5.Endoscopy DivisionNational Cancer Center HospitalTokyoJapan
  6. 6.Colorectal Surgery DivisionNational Cancer Center HospitalTokyoJapan
  7. 7.Department of Molecular ToxicologyGraduate School of Medical Sciences, Nagoya City UniversityNagoyaJapan
  8. 8.National Cancer CenterTokyoJapan

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