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Effect of FeSO4 treatment on glucose metabolism in diabetic rats

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Abstract

Iron, the prosthetic group of haemoglobin, was found to lower serum glucose levels of diabetic rats. Its regulative mechanism and effects on enzymatic activities of glucose metabolism are still unknown. In this study, the correlation between iron supply and enzymatic activities of glucose metabolism and respiratory chain were evaluated in liver and kidney tissues of alloxan induced-diabetic rats. After FeSO4 and metformin administration, serum samples were collected for serum glucose and fructosamine level measurements. Kidney and liver tissues were excised at the end of the study for assaying enzymatic activities of isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH-dehydrogenase and cytochrome-c-oxidase. Results showed significantly decreased serum glucose and fructosamine levels in treatment groups and enhanced enzymatic activities of several proteins as compared with the diabetic control group. Therefore, these data suggested that FeSO4 administration could increase the supply of oxygen, enhance enzymatic activities of glucose metabolism and the respiratory chain, accelerate glucose metabolism and consequently decrease serum glucose levels.

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Acknowledgements

This work was supported by by a grant from National Science Fund for Creative Research Groups (Grant No.40721002), a grant from Research Foundation for Advanced Talents of Jiangsu University (1821360005) and Anhui biotechnological technology company.

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Authors and Affiliations

  1. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou, 550002, People’s Republic of China

    Zhicai Zhang & Bin Lian

  2. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, People’s Republic of China

    Zhicai Zhang & Fengjie Cui

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  1. Zhicai Zhang
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  2. Bin Lian
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  3. Fengjie Cui
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Correspondence to Bin Lian.

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Zhang, Z., Lian, B. & Cui, F. Effect of FeSO4 treatment on glucose metabolism in diabetic rats. Biometals 21, 685–691 (2008). https://doi.org/10.1007/s10534-008-9153-8

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