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Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats

Biometals volume 18, pages 207–212 (2005)Cite this article

Abstract

Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with increased sperm abnormalities was also observed in NaF-exposed male rats. The activity levels of testicular steroidogenic marker enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD) were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats exposed to NaF.

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Authors and Affiliations

  1. Department of Biotechnology, Sri Venkateswara University, Tirupati, 517 502, India

    T. Pushpalatha, M. Srinivas & P. Sreenivasula Reddy

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  1. T. Pushpalatha
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  2. M. Srinivas
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  3. P. Sreenivasula Reddy
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Correspondence to P. Sreenivasula Reddy.

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Pushpalatha, T., Srinivas, M. & Sreenivasula Reddy, P. Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats. Biometals 18, 207–212 (2005). https://doi.org/10.1007/s10534-005-0336-2

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  • DOI: https://doi.org/10.1007/s10534-005-0336-2

Keywords

  • sodium fluoride
  • sperm
  • male rat
  • testes
  • steroidogenic marker enzymes