, Volume 18, Issue 3, pp 207–212 | Cite as

Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats

  • T. Pushpalatha
  • M. Srinivas
  • P. Sreenivasula ReddyEmail author


Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with increased sperm abnormalities was also observed in NaF-exposed male rats. The activity levels of testicular steroidogenic marker enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD) were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats exposed to NaF.


sodium fluoride sperm male rat testes steroidogenic marker enzymes 


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Copyright information

© Springer 2005

Authors and Affiliations

  • T. Pushpalatha
    • 1
  • M. Srinivas
    • 1
  • P. Sreenivasula Reddy
    • 1
    Email author
  1. 1.Department of BiotechnologySri Venkateswara UniversityTirupatiIndia

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