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Pre-administration of rats with Helicobacter pylori γ-glutamyl-transpeptidase alleviates osteoarthritis

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Abstract

Objective

To determine the efficacy of Helicobacter pylori γ-glutamyl-transpeptidase (GGT) in osteoarthritis (OA) therapy.

Results

Oral administration of rats with rGGT alleviated joint pain in the acute phase of iodoacetate (IA)-induced OA. The CXCL1/IL-6 in blood and in articular tissue as well as circulating granulocytes in the recipients of GGT, were reduced. This might be associated with the expansion of regulatory T cells in the inguinal lymph nodes and increased articular IL-10.

Conclusion

We provide preclinical evidence that H. pylori GGT may represent a promising candidate for OA therapy.

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Supporting information

Supplementary Table 1—Q-PCR primer sequences.

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Authors and Affiliations

  1. Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People’s Republic of China

    Xiaofeng Yang

  2. Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Nanjing University of Chinese Medicine, Changzhou, Jiangsu, 213003, People’s Republic of China

    Zhengxiang Lv, Guohua Xie, Feng Xue & Chao Chen

  3. Department of Orthopedics, Wuxi Traditional Chinese Medicine Hospital, Nanjing University of Chinese Medicine, Wuxi, Jiangsu, 214071, People’s Republic of China

    Jianwei Wang

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  1. Xiaofeng Yang
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  2. Zhengxiang Lv
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  3. Guohua Xie
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  4. Feng Xue
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  5. Chao Chen
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Corresponding author

Correspondence to Jianwei Wang.

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Yang, X., Lv, Z., Xie, G. et al. Pre-administration of rats with Helicobacter pylori γ-glutamyl-transpeptidase alleviates osteoarthritis. Biotechnol Lett 40, 521–526 (2018). https://doi.org/10.1007/s10529-017-2495-y

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  • DOI: https://doi.org/10.1007/s10529-017-2495-y

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