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miR-215 functions as an oncogene in high-grade glioma by regulating retinoblastoma 1

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Abstract

Objectives

To investigate the roles of miR-215 in high-grade glioma and to clarify the regulation of retinoblastoma 1 (RB1) by miR-215.

Results

miR-215 is frequently up-regulated in high-grade glioma tissues. Increased miR-215 expression is significantly associated with World Health Organization grade (P < 0.01) tumor size (P < 0.05) and poor prognosis (P < 0.01). Over-expression of miR-215 promoted cell proliferation and knockdown of miR-215 inhibited cell proliferation in vitro. RB1 was identified as a direct and functional target of miR-215. RB1 is generally down-regulated in glioma tissues and its expression inversely correlated with miR-215, which is up-regulated in high-grade glioma tissues, and its expression was negatively correlated with miR-215.

Conclusions

The new miR-215/RB1 axis provides new insights into the molecular mechanism and treatment for glioma.

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Authors and Affiliations

  1. Department of Neurosurgery, First Affiliated Hospital, Henan University of Science & Technology, No. 36 Tongji Street, Luonan New District, Luoyang, 471003, Henan, People’s Republic of China

    Xiaofeng Meng & Baozhong Shi

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  1. Xiaofeng Meng
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  2. Baozhong Shi
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Correspondence to Baozhong Shi.

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The author declares that they have no competing interest.

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Meng, X., Shi, B. miR-215 functions as an oncogene in high-grade glioma by regulating retinoblastoma 1. Biotechnol Lett 39, 1351–1358 (2017). https://doi.org/10.1007/s10529-017-2373-7

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  • DOI: https://doi.org/10.1007/s10529-017-2373-7

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