The lacrimal gland: development, wound repair and regeneration
The lacrimal gland (LG) is important as it has a significant role in maintaining the stability of the microenvironment of the ocular surface. When a loss of function occurs in the LG, a significant reduction in tear production and dry eye disease (DED) may occur. A mammalian LG is a secretory gland consisting of acini and ducts. The interaction between epithelial cells and mesenchymal cells plays a major role during development and the self-restoration process of the gland. Some factors, such as fibroblast growth factor 10 and bone morphogenetic protein 7, are associated with these processes. Though several strategies for LG regeneration have been established, there is still a long way to go before there is clarity about LG stem cells. In this review, current knowledge on LG development, LG self-repair, DED and correlative regeneration therapies are summarized.
KeywordsAutotransplantation Bioengineered gland Development Dry eye disease Lacrimal gland Stem cell
This study was supported in part by a Grant from National High Technology Research and Development Program of China (No. 2014AA020702), National Natural Science Foundation of China (No. 31371390) and Ph.D. Programs Foundation of Ministry of Education of China (No. 20130171110010). We thank Sa Xiao for suggestive discussion.
- Hann LE, Tatro JB, Sullivan DA (1989) Morphology and function of lacrimal gland acinar cells in primary culture. Investig Ophthalmol Vis Sci 30:145–158Google Scholar
- O’Rahilly R, Müller F (1996) Human embryology & teratology. Wiley-Liss, New YorkGoogle Scholar
- Roth M, Spaniol K, Kordes C, Schwarz S, Mertsch S, Haussinger D, Rotter N, Geerling G, Schrader S (2015) The influence of oxygen on the proliferative capacity and differentiation potential of lacrimal gland-derived mesenchymal stem cells. Investig Ophthalmol Vis Sci 56:4741–4752CrossRefGoogle Scholar
- Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC (2001) Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Investig Ophthalmol Vis Sci 42:2283–2292Google Scholar
- Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, Elting LS, Langendijk JA, Coppes RP, Reyland ME (2010) Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys 78:983–991CrossRefPubMedPubMedCentralGoogle Scholar
- Zoukhri D, Hodges RR, Byon D, Kublin CL (2002) Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. Investig Ophthalmol Vis Sci 43:1429–1436Google Scholar