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RETRACTED ARTICLE: MicroRNA-215 enhances invasion and migration by targeting retinoblastoma tumor suppressor gene 1 in high-grade glioma

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This article was retracted on 23 July 2022

This article has been updated

Abstract

Objective

To elucidate the molecular mechanism of microRNA-215 (miR-215) in the migration and invasion of high grade glioma.

Results

42 Patients were analysed for clinicopathological characteristics. qRT-PCR showed that miR-215 was up-regulated in glioma tissues compared with non-neoplastic brain tissues (P < 0.05). The up-regulated miR-215 was closely associated with high grade glioma (P < 0.01) and poor overall survival (P < 0.01). Transwell assay showed that re-expression of miR-215 enhanced migration and invasion of glioma cells. miR-215 also down-regulated retinoblastoma tumor suppressor gene 1 (RB1) expression by targeting its 3′-UTR. Reversely, re-expression of RB1 inhibited partial effect of miR-215 on migration and invasion in vitro.

Conclusions

Re-expression of miR-215 promoted cell migration and invasion of glioma by targeting RB1. miR-215 can thus be used as a biomarker for tumor progression and prognosis in human high grade glioma.

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Author notes

    Authors and Affiliations

    1. Department of Neurosurgery, Qilu Hospital of Shandong University, 107 of Wenhua Xi Road Lixia District, Jinan, 250012, Shandong, People’s Republic of China

      Yuzhen Wei & Xingang Li

    2. Department of Neurosurgery, Jining No.1 People’s Hospital, Jining, Shandong, People’s Republic of China

      Yuzhen Wei

    3. Department of Endocrinology, Jining No.1 People’s Hospital, Jining, 272 011, Shandong, People’s Republic of China

      Jianjing Sun

    4. Brain Science Research Institute, Shandong University, Jinan, Shandong, People’s Republic of China

      Xingang Li

    Authors
    1. Yuzhen Wei
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    2. Jianjing Sun
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    3. Xingang Li
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    Corresponding author

    Correspondence to Xingang Li.

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    Yuzhen Wei and Jianjing Sun have equally contributed to this work.

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    Wei, Y., Sun, J. & Li, X. RETRACTED ARTICLE: MicroRNA-215 enhances invasion and migration by targeting retinoblastoma tumor suppressor gene 1 in high-grade glioma. Biotechnol Lett 39, 197–205 (2017). https://doi.org/10.1007/s10529-016-2251-8

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    • DOI: https://doi.org/10.1007/s10529-016-2251-8

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