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Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

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An Erratum to this article was published on 11 July 2016

Abstract

Objective

To investigate whether electrospun silk fibroin (SF) mat wrapping could enhance tendon-bone healing of soft tissue graft.

Results

Rabbit bone marrow-derived mesenchymal stem cells proliferated well on electrospun SF mat. The autologous Achilles tendon wrapped with electrospun SF mat was transplanted into the bone tunnel (experimental group) in a rabbit extra-articular model, while the unwrapped tendon was transplanted as control group. The electrospun SF mat wrapping could enhance tendon-bone healing of autologous tendon evaluated by micro-computed tomography scanning, histological examination and mechanical testing. At 6 and 12 weeks post-operatively, the failure loads of experimental group were both significantly higher than those of control group (40.5 ± 6.3 vs. 31.8 ± 4.6 N, P = 0.039 at 6 weeks; 67.1 ± 9. vs. 52.2 ± 4.7 N, P = 0.012 at 12 weeks).

Conclusion

The electrospun SF mat wrapping could enhance tendon-bone healing of soft tissue graft.

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Acknowledgments

This study was funded by the National 863 Hi-tech Project (2015AA033703) from the Ministry of Science and Technology of the People’s Republic of China.

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Authors and Affiliations

  1. Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, 200040, Shanghai, People’s Republic of China

    Yunlong Zhi, Peng Zhang, Jia Jiang & Shiyi Chen

  2. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, People’s Republic of China

    Wen Liu

Authors
  1. Yunlong Zhi
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  2. Wen Liu
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  3. Peng Zhang
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  4. Jia Jiang
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  5. Shiyi Chen
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Corresponding author

Correspondence to Shiyi Chen.

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The authors declare that they have no conflict of interest.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10529-016-2171-7.

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Zhi, Y., Liu, W., Zhang, P. et al. Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model. Biotechnol Lett 38, 1827–1835 (2016). https://doi.org/10.1007/s10529-016-2158-4

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  • DOI: https://doi.org/10.1007/s10529-016-2158-4

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