Biocatalysis and biotransformation of resveratrol in microorganisms
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Resveratrol, a major stilbene phytoalexin, is a valuable polyphenol that has been recognized for its benefits to human health. Resveratrol has antioxidant and antitumor effects and promotes longevity. It is used in medicine, health care products, cosmetics, and other industries. Therefore, a sustainable source for resveratrol production is required. This review describes the metabolic engineering of microorganisms, the biotransformation and biosynthesis of endophytes and the oxidation or degradation of resveratrol. We compare various available methods for resveratrol production, and summarize the practical challenges facing the microbial production of resveratrol. The future research direction for resveratrol is also discussed.
KeywordsBiotransformation 4-Coumarate:coenzyme A ligase Metabolic engineering Resveratrol Stilbene synthase
Thanks for financial supports from the National Natural Science Foundation of China (Project No. 41306139); the National Science Foundation for Talents Training in Basic Science, China (J1103507); a PhD Programs Foundation of Ministry of Education of China (Grant No. 20133207120001), the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions.
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