Abstract
Aromatic ketones were reduced using suspension culture of Chlorella sp. MK201 under fluorescent light illumination producing the corresponding chiral alcohols in high yields with excellent enantiomeric excess (ee). For example, 2′,3′,4′,5′,6′-pentafluoroacetophenone at 0.25 mg/ml was converted to the corresponding (S)-alcohol in 80 % yield with >99 % ee by 1 mg dry wt of Chlorella/ml in 12 h illumination (2,000 lux).
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Acknowledgments
This work was financially supported by the ‘Nihon University College of Science and Technology Symbolic Project on State-of-the-Art Research Initiatives’.
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Itoh, Ki., Nakamura, K., Aoyama, T. et al. Photobiocatalyzed asymmetric reduction of ketones using Chlorella sp. MK201. Biotechnol Lett 34, 2083–2086 (2012). https://doi.org/10.1007/s10529-012-1008-2
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DOI: https://doi.org/10.1007/s10529-012-1008-2