Abstract
Purpose of work
Our study provides a promising alternative of biomimetic coating which functionalizes the dental implant with adhesion peptides and may be useful for enhancing the bone remodeling around Ti implants.
A chimeric peptide consisting of an Arg-Gly-Asp (RGD) sequence (mediating cell adhesion) and a RKLPDA (minTBP-1) sequence (specifically recognizing and binding to Ti substrate) was designed and synthesized. The chimeric peptide affinity to Ti disks, as well as its role in mediating MC3T3-E1 cell attachment and afterwards spreading on pre-coated Ti disks, was investigated. The chimeric peptide not only showed favorable affinity to Ti surfaces but also facilitated the adhesion of MC3T3-E1 cells.
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This study was supported by a grant from the National Science Foundation of China (NSFC No. 30700957).
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Dan Wang and Jing Mao have contributed to this paper equally.
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Wang, D., Mao, J., Zhou, B. et al. A chimeric peptide that binds to titanium and mediates MC3T3-E1 cell adhesion. Biotechnol Lett 33, 191–197 (2011). https://doi.org/10.1007/s10529-010-0411-9
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DOI: https://doi.org/10.1007/s10529-010-0411-9