Abstract
Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
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Acknowledgements
JV-H and SCE-G received a PhD scholarship from the National Council of Science and Technology (CONACYT) of México. This work was supported by a grant to RMDOL from CONACYT of México. The authors thank Archana Monie for critical review of this manuscript.
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Villatoro-Hernandez, J., Arce-Mendoza, A.Y., Rosas-Taraco, A.G. et al. Murine interferon-gamma inducible protein-10 (IP-10) secreted by Lactococcus lactis chemo-attracts human CD3+ lymphocytes. Biotechnol Lett 31, 1795–1800 (2009). https://doi.org/10.1007/s10529-009-0081-7
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DOI: https://doi.org/10.1007/s10529-009-0081-7