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Biotransformation of (±)-2-methylcyclohexanone by fungi

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Abstract

The biotransformation of 2-methylcyclohexanone (1) using 16 fungal strains and some mushroom cultures was investigated. Fusarium sp. was one of the effective biocatalysts for oxidoreduction of 2-methylcyclohexanone (1). cis-2-Methylcyclohexanol (2a) was isomerized to trans-2-methylcyclohexanol (2b) by Fusarium sp. In addition, the corresponding lactones 3 was obtained by Baeyer-Villiger oxidation using Fusarium sp. AP-2 (46%, 94% ee).

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Acknowledgement

This work was partially supported by Frontier Project “Adaption and Evolution of Extremophile” and a Grant-in-Aid for Scientific Research (No. 18550142).

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Authors and Affiliations

  1. Department of Chemistry, Rikkyo (St. Paul’s) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan

    Mai Kawamoto, Takamitsu Utsukihara, Chika Abe, Michiko Sato, Nakahide Kato & C. Akira Horiuchi

  2. National Food Research Institute, 2-1-12 Kannondai, Tsukuba-shi, Ibaraki, 305-8642, Japan

    Michihiko Saito

  3. Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa, 903-0213, Japan

    Masahiro Koshimura

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  1. Mai Kawamoto
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  2. Takamitsu Utsukihara
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  3. Chika Abe
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  4. Michiko Sato
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  5. Michihiko Saito
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  6. Masahiro Koshimura
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  7. Nakahide Kato
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  8. C. Akira Horiuchi
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Correspondence to C. Akira Horiuchi.

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Kawamoto, M., Utsukihara, T., Abe, C. et al. Biotransformation of (±)-2-methylcyclohexanone by fungi. Biotechnol Lett 30, 1655–1660 (2008). https://doi.org/10.1007/s10529-008-9729-y

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  • DOI: https://doi.org/10.1007/s10529-008-9729-y

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