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An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus

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Growth of Streptococcus zooepidemicus in a 10 l bioreactor with 50 g sucrose/l and 10 g casein hydrolysate/l gave 5–6 g hyaluronic acid/l after 24–28 h. Purification of hyaluronic acid gave a recovery of 65% with the final material having an Mr of ∼4 × 106 Da with less than 0.1% protein.

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The authors gratefully acknowledge the encouragement and support of Reliance Life Sciences Pvt. Ltd., in carrying out the research work.

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Correspondence to Vidhya Rangaswamy.

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Rangaswamy, V., Jain, D. An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus . Biotechnol Lett 30, 493–496 (2008).

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