Abstract
The effects of inducible materials (dexamethasone and ascorbate) on chondrogenic differentiation of rabbit chondrocytes have been examined. A hydrogel construct containing dexamethasone and ascorbate up-regulated gene expression of the cartilage matrix component of collagen to give three times the collagen content per construct at day 56 as compared to controls. Alcian Blue and Safranin-O staining revealed that these constructs also had formed more hyaline cartilage than other hydrogel constructs.
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This work was supported by a Korea Research Foundation Grant (KRF2005-D00961).
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The first two authors Kun Na and Seong-Jun Choi equally contributed to this work.
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Na, K., Choi, SJ., Kim, S. et al. Enhancement of cell proliferation and differentiation by combination of ascorbate and dexamethasone in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes. Biotechnol Lett 29, 1453–1457 (2007). https://doi.org/10.1007/s10529-007-9420-8
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DOI: https://doi.org/10.1007/s10529-007-9420-8