Abstract
The cancer-associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of it increased phosphorylation of focal adhesion kinase (FAK) and enhanced motility of SNU387 cells. Focal adhesion, kinase-related non-kinase (FRNK), an endogenous inhibitor of FAK, was significantly suppressed. This suggests that CAGE-promoted motility requires FAK. The inhibition of Rho-Associated coiled-coil-containing protein kinase (ROCK), an activator of FAK, also suppressed CAGE-promoted motility.
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Acknowledgments
This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular Research Center, Korea Research Foundation (0805011-1-1), and from the Ministry of Health and Welfare of Korea (A050260). This work was also supported by a grant from Kangwon National University.
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Shim, H., Lee, H. & Jeoung, D. Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK). Biotechnol Lett 28, 2057–2063 (2006). https://doi.org/10.1007/s10529-006-9190-8
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DOI: https://doi.org/10.1007/s10529-006-9190-8