Skip to main content

Advertisement

SpringerLink
Log in

CAGE Displays Oncogenic Potential and Induces Cytolytic T Lymphocyte Activity

  • Published:
Biotechnology Letters Aims and scope Submit manuscript

Abstract

The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Y Akao O Marukawa H Morikawa K Nakao M Kamei T Hachiya Y Tsujimoto (1995) ArticleTitleThe rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues Cancer Res. 55 3444–3449 Occurrence Handle1:CAS:528:DyaK2MXnt1ant74%3D Occurrence Handle7614484

    CAS  PubMed  Google Scholar 

  • P Boel (1995) ArticleTitleBAGE: A new gene encoding for an antigen recognized on human melanoma Immunity 2 167–175 Occurrence Handle10.1016/S1074-7613(95)80053-0 Occurrence Handle1:CAS:528:DyaK2MXjvVCqtrw%3D Occurrence Handle7895173

    Article  CAS  PubMed  Google Scholar 

  • B Cho H Lee S Jeong Y Bang H Lee K Hwang H Kim Y Lee G Kang D Jeoung (2003) ArticleTitlePromoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma Biochem. Biophys. Res. Commun. 307 52–63 Occurrence Handle10.1016/S0006-291X(03)01121-5 Occurrence Handle1:CAS:528:DC%2BD3sXkvFGiu74%3D Occurrence Handle12849980

    Article  CAS  PubMed  Google Scholar 

  • B Cho Y Lim D Lee S Park H Lee W Kim H Yang Y Bang D Jeoung (2002) ArticleTitleIdentification and characterization of a novel cancer/testis antigen gene CAGE Biochem. Biophys. Res. Commun. 292 715–726 Occurrence Handle1:CAS:528:DC%2BD38XitlGmsr8%3D Occurrence Handle11922625

    CAS  PubMed  Google Scholar 

  • O Backer ParticleDe KC Arden M Boretti V Vantomme C Smet ParticleDe S Czekay C Viars E Plaen ParticleDe F Brasseur P Chomez B Eynde ParticleVan den T Boon P Bruggen Particlevan der (1999) ArticleTitleCharacterization of the GAGE genes that are expressed in various human cancers and in normal testis Cancer Res. 59 3157–3165 Occurrence Handle10397259

    PubMed  Google Scholar 

  • S Lucas C Smet ParticleDe KC Arden CS Viars B Lethe C Lurquin T Boon (1998) ArticleTitleIdentification of a new MAGE gene with tumor-specific expression by representational difference analysis Cancer Res. 58 743–752 Occurrence Handle1:CAS:528:DyaK1cXht1anurY%3D Occurrence Handle9485030

    CAS  PubMed  Google Scholar 

  • S Park Y Lim D Lee B Cho Y Bang S Sung H Kim D Kim Y Lee Y Song D Jeoung (2003) ArticleTitleIdentification and characterization of a novel cancer/testis antigen gene CAGE-1 Biochem. Biophys. Acta 1625 173–182 Occurrence Handle1:CAS:528:DC%2BD3sXjt1Sjuw%3D%3D Occurrence Handle12531476

    CAS  PubMed  Google Scholar 

  • N Sadanaga H Nagashima K Mashino K Tahara H Yamaguchi M Ohta T Fujie F Tanaka H Inoue K Takesako T Akiyoshi M Mori (2001) ArticleTitleDendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinoma Cancer Res. 7 2277–2284 Occurrence Handle1:CAS:528:DC%2BD3MXmsVOmtrg%3D

    CAS  Google Scholar 

  • C Urbich E Dernbach A Aicher AM Zeiher S Dimmeler (2002) ArticleTitleCD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species Circulation 106 981–986 Occurrence Handle10.1161/01.CIR.0000027107.54614.1A Occurrence Handle1:CAS:528:DC%2BD38XntlSqs7w%3D Occurrence Handle12186804

    Article  CAS  PubMed  Google Scholar 

  • J Weber M Salgaller D Samid B Johnson M Herlyn N Lassam J Treisman S Rosenberg (1994) ArticleTitleExpression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2′-deoxycytidine Cancer Res. 54 1766–1771 Occurrence Handle1:CAS:528:DyaK2cXisVajtrw%3D Occurrence Handle7511051

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biological Sciences, College of Natural Sciences, Kangwon National University, 200-701, Chunchon, Republic of Korea

    Eunsook Shim, Hyeeun Shim, Jinhee Bae, Hansoo Lee & Dooil Jeoung

Authors
  1. Eunsook Shim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hyeeun Shim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jinhee Bae
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hansoo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dooil Jeoung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dooil Jeoung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shim, E., Shim, H., Bae, J. et al. CAGE Displays Oncogenic Potential and Induces Cytolytic T Lymphocyte Activity. Biotechnol Lett 28, 515–522 (2006). https://doi.org/10.1007/s10529-006-0008-5

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10529-006-0008-5

Keywords

Search

Navigation