Abstract
Nω-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl (Nω-Pbf)-protected oligoarginine was directly conjugated to poly(amino acid) derivatives modified with a long alkyl chain. The final concentration of conjugated peptides was easily controlled by the feed ratio of oligoarginine to polymer backbone and a final soluble polymeric system was obtained by the deprotection of Nω-Pbf groups. The polymeric conjugates formed stable self-aggregates of size range of 8–40 nm in aqueous solution and effectively internalized into HeLa cells by adsorptive endocytosis.
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Revisions requested 8 April 2005; Revisions received 6 May 2005
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Yang, S.R., Kim, S.B., Joe, C.O. et al. Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery. Biotechnol Lett 27, 977–982 (2005). https://doi.org/10.1007/s10529-005-7838-4
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DOI: https://doi.org/10.1007/s10529-005-7838-4